海德堡OCT测量后极部视网膜厚度对青光眼诊断价值  

THE DIAGNOSTIC VALUE OF MEASUREMENT OF POSTERIOR POLE RETINAL THICKNESS WITH HEIDELBERG OCT IN GLAUCOMA

作　　者：邢业娇[1] 王大博[1] 纪珍[1] 刘鹏辉[1] 

机构地区：[1]青岛大学医学院附属医院眼科,山东青岛266003

出　　处：《青岛大学医学院学报》2013年第1期38-40,43,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的利用光学相干断层扫描技术(OCT)观察正常眼和青光眼后极部视网膜厚度,评价其对青光眼的诊断价值。方法采用海德堡Spectralis OCT对40例(40眼)正常人和41例(64眼)青光眼(包括53眼POAG和11眼PACG)病人后极部视网膜厚度进行测量,观察正常人和青光眼病人后极部视网膜厚度地形图的图像特征并进行比较;并分析其与视野平均缺损值(MD)的相关性。结果正常人后极部视网膜厚度地形图呈"马蹄形",青光眼病人后极部"马蹄形"特征不典型或"马蹄形"消失;正常人后极部视网膜平均、上方、下方厚度比较差异无显著性(F=0.800,P>0.05),青光眼病人后极部各区域视网膜厚度均较正常人下降,差异有显著性(F=59.569～72.364,P<0.01);早期青光眼病人后极部视网膜厚度也较正常人下降,差异有显著性(t=2.828,P<0.01);青光眼病人后极部平均视网膜厚度与视野MD呈负相关(r=-0.619,P<0.01)。结论青光眼后极部视网膜厚度改变与视野功能改变有良好的相关性,且较视野缺损出现早,有可能作为视神经节细胞丢失监测的替代观察指标。Objective To observe the posterior pole retinal thickness of normal and glaucoma measured by optical cohe- rence tomognaphy （OCT）, and evaluate its value in the diagnosis of glaucoma. Methods The thickness of posterior pole retina of 40 normal cases （40 eyes） and 41 glaucoma （64 eyes, including 53 POAG and 11 PACG） were respectively measured by Heidel- berg Spectralis OCT. The image features of posterior pole retinal mapping in normal individuals and patients with glaucoma were observed and compared, the correlation between MD and retinal thickness was calculated as well. Results The posterior pole retinal mapping in normal persons appeared as U-shaped, and that shape was not typical or disappeared in glaucoma. There was no statistical difference among the thickness of posterior pole retinal in average, superior and inferior in health adult group （F = 0. 800,P〉0.05）, in patients with glaucoma, the thickness of posterior pole retinal was thinner than that in normal group （F= 59. 569-72. 364,P〈0.01） ; the same finding was also appeared in early glaucoma （t=2. 828,P〈0.01）. The posterior pole reti- nal thickness in glaucoma was negatively correlated with MD （r= -0. 619 ,P〈0. 01）. Conclusion In glaucoma, the changes of thickness of posterior pole retina have a close correlation with changes of function of visual field, and appear earlier than defect of visual field, which is likely to be a marker to replace detection of retinal ganglion cell loss.

关 键 词：体层摄影术 光学相干 青光眼 视网膜 视野 

分 类 号：R775[医药卫生—眼科]