EZH2在原发性肝癌中的表达及与分化和增殖的关系  

Expression of EZH2 and its relation to differentiation and proliferation in hepatocellular carcinoma

作　　者：曹相玫[1,2] 王映梅[1] 谷雨[1] 蒋丽娜[1] 李青[1] 

机构地区：[1]第四军医大学附属西京医院病理科肿瘤生物学国家重点实验室,陕西西安710032 [2]宁夏医科大学病理学系,宁夏银川750004

出　　处：《现代肿瘤医学》2013年第3期453-456,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81000171;8170798);肿瘤生物学国家重点实验室开放基金项目(编号:CBSKL 201103)

摘　　要：目的:探讨EZH2的表达水平与原发性肝癌(HCC)的恶性程度和增殖能力的关系及其意义。方法:采用HE染色判断HCC的分化级别;免疫组化SP法检测EZH2与Ki67蛋白在不同分化级别HCC组织中的表达水平。结果:EZH2在HCC组织中的表达率显著高于正常肝组织(P<0.05);EZH2的表达水平随着HCC分化程度的降低而明显升高(P<0.05);EZH2与Ki67蛋白在不同分化级别的HCC中表达趋势一致。结论:HCC中EZH2蛋白的表达水平显著升高,与肿瘤的分化程度和增殖相关,提示EZH2可为判断HCC病理分级和增殖能力提供参考。Objective： To study the expression of EZH2 gene in hepatocellular carcinoma （ HCC）, and investigate the relationship between EZH2 gene and the differentiation and proliferation of HCC and pathological significance. Methods： HE staining was used to measure the level of differentiation of HCC, immunohistochemistry were used to de- tect the expression of EZH2 and Ki67 protein in HCC tissues. Results：The expression of EZI-I2 in HCC significantly increased than normal hepatic tissue （P 〈 0.05 ）, with decreasing of the differentiated degree, the positive expression of EZH2 protein was significantly higher in HCC （ P 〈 0.05 ）. The trends of positive expression of EZH2 and Ki67 protein had consistency. Conclusion： Increased expression of EZH2 was shown in HCC and related to tumor differenti- ation degree and proliferation, it may be valuable for pathological diagnosis.

关 键 词：HCC EZH2 KI67 分化 增殖 

分 类 号：R730[医药卫生—肿瘤] R735.7[医药卫生—临床医学]