阿尔茨海默病患者局部脑血流量及脑血管反应性研究  

The study of regional cerebral blood flow and cerebrovascular reactivity in Alzheimer's disease

作　　者：高永哲[1] 章军建[1] 吴光耀[2] 刘晖[1] 张洪[1] 熊丽[1] 

机构地区：[1]武汉大学中南医院神经科,湖北武汉430071 [2]武汉大学中南医院放射科,湖北武汉430071

出　　处：《中风与神经疾病杂志》2013年第2期120-123,共4页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金面上项目(No.30970962)

摘　　要：目的了解阿尔茨海默病患者(AD)相对正常老年人局部脑血流量(rCBF)以及脑血管反应性(CVR)的变化特征及规律。方法应用动脉自旋标记核磁共振技术(ASL)首先定量测定静息状态下两组病例rCBF,然后分别吸入5%的CO2各1min,再次测定rCBF,并计算其增加率以代表CVR。结果相比对照组,AD组在双侧额叶、颞叶、顶叶的皮质及皮质下均有显著性的rCBF降低,但仅在双侧额叶皮质有显著性的CVR下降。结论广泛的皮质及皮质下rCBF降低以及双侧额叶皮质CVR的下降可能是AD的一个重要临床客观指标。Objective To Iinvestigate the different patterns of regional cerebral blood flow （rCBF） change and cere- brovascular reactivity in Alzheimer＇ s disease comparing to normal old peopleelder. Methods rCBF of two groups were measured by arterial spin-labeling （ASL） magnetic resonance ,separately. CVR was evaluated by rCBF change in response to 5% CO2 inhalation for 1 minute. Results The ASL results showed that rCBF was significantly lower in both the bilateral frontal, parietal and temporal lobes includinge eorteixces and white matters in AD group, but CVR calculated by rCBF was only severely impaired only severely in bilateral frontal cortexices in AD. Conclusion The extensive decline of rCBF in cortexices and white matters ,especially the CVR impaired severely in bilateral frontal cortexices may be a ＂biomarker＂ in AD.

关 键 词：阿尔茨海默病 局部脑血流量 脑血管反应性 动脉自旋标记核磁共振 

分 类 号：R749.1[医药卫生—神经病学与精神病学]