心脏卵圆孔未闭对不同年龄人群隐源性卒中的影响  

Effect of patent foramen ovale on cryptogenic stroke in different age groups

作　　者：蔡高昂[1] 张爱梅[2] 李宪章[2] 高正科[1] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]济宁医学院附属医院神经内科,山东济宁272029

出　　处：《中风与神经疾病杂志》2013年第2期144-147,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨心脏卵圆孔未闭(patent foramen ovale,PFO)与不同年龄人群隐源性脑卒中(cryptogenicstroke,CS)的关系。方法从238例中青年(<55岁)和373例老年(≥55岁)急性脑梗死患者中筛查出181例隐源性卒中患者,为隐源性卒中组,根据年龄分为两亚组:中青年CS组(<55岁)和老年CS组(≥55岁),并分别设立同年龄段的非卒中患者为对照组。隐源性卒中组及对照组均进行发泡实验明确是否存在PFO。多因素Logistic回归分析用来检验PFO和隐源性卒中间的关系。结果 PFO在中青年CS患者及老年CS患者中都明显高于其对照组相,差异都具有统计学意义(P值分别为0.005和0.023);校正年龄等因素后,多因素Logistic回归分析显示无论中青年(P<0.01)还是老年(P<0.05),PFO都是隐源性卒中的独立危险因素;PFO在CS两亚组间差异不明显(P>0.05),没有统计学意义。结论无论中青年及老年,PFO都是CS的独立危险因素,年龄不是影响PFO与CS关系的主要因素。Objective To explore the relationship between patent foramen ovale（PFO） and cryptogenic stroke（CS） in different age groups. Methods From 238 young and middle-aged（ 〈55years old） and 373 aged（ ≥55 years old） pa- tients with acute brain infarction, 118 CS patients were screened as CS group and divided into 2 subgroups ： young and mid- dle-aged CS group （ 〈 55years old ） and aged CS group （ ≥ 55 years old ）. Non stroke patients were enrolled as control group. Both CS group and control group had bubble study to determine the presence of PFO or not. Multivariate logistic re- gression analysis was used to test the association between PFO and cryptogenic stroke. Results The frequencies of PFO in young and middle-aged CS patients and in aged CS patients were much higher than in their control groups, and the differ- ences were all statistical significant（ P value was 0. 005 and 0. 023 ）. After adjusting for age and other factors, multivariate logistic regression analysis showed that PFO was an independent risk factor both for CS in young and middle-aged patients （P 〈 0.01 ）and in aged patients（ P 〈 0.05 ）. There was no significant difference for the frequency of PFO between two CS subgroups, and it had no statistical significance （ P 〉 0.05 ）. Conclusion The presence of PFO was an independent risk factor for CS both in young and middle-aged patients and in aged patients, and age was not a main factor affecting the associ- ation between PFO and CS.

关 键 词：卵圆孔未闭 脑梗死 发泡实验 隐源性卒中 

分 类 号：R743[医药卫生—神经病学与精神病学]