脂氧素——抗组织纤维化的新药物  

Lipoxins——A Novel Drug for Tissue Fibrosis

作　　者：余忠建[1] 周晓燕[2] 闵卫平[3,4] 

机构地区：[1]南昌大学医学院药理学教研室 [2]南昌大学医学院病理生理学教研室 [3]南昌大学医学院 [4]江西省医学科学研究院,南昌330006

出　　处：《中国生物化学与分子生物学报》2013年第3期213-217,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81100299);江西省自然科学基金(No.20114BAB215010);江西省卫生厅科技计划项目(No.20122020)~~

摘　　要：组织纤维化是器官组织内纤维结缔组织增多而实质细胞减少的一类疾病,组织损伤导致的慢性炎症反应是纤维化形成的根本原因.脂氧素是体内重要的内源性促炎症消退介质,兼具抗炎和促炎症消退双重作用,对多种炎症细胞和炎症相关基因有显著的负性调节作用,为炎症反应的重要"刹车信号".脂氧素可以促进炎症及时消退而防止其蔓延为慢性炎症,因此,它极有可能在抑制纤维化的形成中起到至关重要的作用.近年来,随着对脂氧素研究的不断深入,其抗纤维化作用日益凸显,成为极有价值的抗纤维化潜在药物.Fibrosis is characterized with disorders that the fiber in connective tissue increases and the parenchyma cells decreases. Chronic inflammation caused by tissue damage is the common of fibrosis. Lipoxins are important endogenous lipid mediators of anti-inflammation functions, which have significant negative regulatory effect on a variety of inflammatory cells and related genes, serving as a ＂brake signal＂ to inflammatory responses. As the research of lipoxin progressed in recent years, the role of lipoxins to suppress immune response and attenuate the chronic inflammation progression are better understood. It is also suggested that lipoxins may be a crucial regulator to inhibit the formation of tissue fibrosis, and therefore might be used as a potential anti-fibrosis drug

关 键 词：脂氧素 炎症 组织纤维化 

分 类 号：R364.5[医药卫生—病理学]