一种新的制备兽药地昔尼尔的方法  

A new method for preparation of veterinary dicyclanil

作　　者：吕新宇[1] 罗鸿[1,2] 吴建才 邱滔[1] 

机构地区：[1]常州大学设计研究院,常州213164 [2]江苏省兽用抗寄生虫药物工程技术中心,常州213127

出　　处：《中国抗生素杂志》2013年第3期214-217,222,共5页Chinese Journal of Antibiotics

摘　　要：目的采用新的合成路线制备兽药地昔尼尔(dicyclanil)。方法以N-氰亚胺基-S,S-二硫代碳酸二甲酯、丙二腈、盐酸、环丙胺等为基础原料,经过缩合、环合、取代、氧化、氨化等反应步骤得到高品质的地昔尼尔。结果通过设计的新的合成路线成功得到高品质的地昔尼尔产品,HPLC分析其含量≥99.9%。结论该合成工艺,工艺操作简单,设备要求低,生产收率高,适于工业生产。Objective This article provided a new synthetic route of preparation of veterinary drugs dicyclanil. Methods Dimethyl cyanimino dithiocarbonate, malononitrile, hydrochloric acid and cyclopropylamine were used as basic raw materials, which would undergo condensation reaction, cyclization reaction, substitution reaction, oxidation and ammoniation to produce final high-quality dicyclanil. Results This new synthetic route could produce high- quality API dicyclanil（the content analysis by HPLC, ≥99.9%）. Conclusion The operation of this synthetic process was simple, its equipment requirement was low, and the production efficiency was high, it could be fit for industrial production.

关 键 词：地昔尼尔 荒酸二甲酯 丙二腈 几丁质抑制剂 

分 类 号：R914.5[医药卫生—药物化学]