胃癌组织Artemin和MMP-9表达与浸润转移相关性分析  

Expression of Artemin and MMP-9 in gastric carcinoma tissues and its relationship with invasion and metastasis

作　　者：曹学全[1] 卢洪胜[1] 章辉[1] 孙刚[1] 杨朝晖[1] 王四玲[1] 

机构地区：[1]台州市中心医院病理科,浙江台州318000

出　　处：《中华肿瘤防治杂志》2013年第4期266-268,272,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨胃癌和癌旁组织中Artemin和MMP-9的表达情况及其与浸润转移的关系,分析两种蛋白表达之间的关系。方法:应用免疫组化EnVision法检测80例胃癌组织和20例癌旁组织(距肿瘤边缘>5cm)中Artemin和MMP-9的表达,并分析其与胃癌临床病理特征的关系。结果:胃癌组织Artemin和MMP-9蛋白阳性表达率分别为78.75%(63/80)和68.75%(55/80),明显高于癌旁组织的10.00%(2/20)和15.00%(3/20),差异有统计学意义(χ2=33.242,P=0.000;χ2=18.976,P=0.000)。胃癌组织Artemin和MMP-9蛋白阳性表达均与临床分期、浸润深度及淋巴结转移有关(P<0.05),而与患者年龄、性别、肿瘤大小及分化程度无关,P>0.05。两者阳性表达呈正相关,r=0.705,P=0.000。结论:Artemin和MMP-9蛋白高表达均与胃癌的发生及浸润转移密切相关,联合检测Artemin和MMP-9蛋白表达情况可能成为评估胃癌患者预后指标及潜在肿瘤生物学治疗的新靶点。OBJECTIVE： To study the expression of Artemin and MMP-9 in gastric carcinoma tissues and corre- sponding para-carcinoma gatric mucosa and its relationship with invasion and metastasis, analyzing the relationship be tween expression of artemin and MMP-9 protein. METHODS： The expressions of artemin and MMP 9 in 80 samples in cluding gastric carcinoma and corresponding para-carcinoma gatric mucosa tissues in gastric carcinoma were deteted by im- munohitochemical EnVision method,and its relationship with clinical pathological characteristic of gastric carcinoma was analyzed. RESULTS： The positive expressions of Artemin and MMP-9 in gastric carcininoma tissues were 78. 750% （63/80） and 68. 75 % （55/80） respectively, which were significantly higher than those in corresponding para-carcinoma gatric mucosa tissues （10.00%15.00% X2 = 33. 242,P=0. 000;7.X2 = 18. 976,P^0. 000）. The positive expressions of Artcmin and MMP-9 in gastric carcinoma tissues were correlated with clinical stage,infiltration depth and lymoh node me- tastasis （P〈0.05）, but not correlated with age, sex, tumor size or degree of differentiation （P〉0.05）. Exressions of Ar- retain were negatively associated with expression of MMP-9 （r--0. 705, P--0. 000）, CONCLUSIONS： The high expres- sions of Artemin and MMP 9 are both closely relative to occurrence,infiltration and metastasis. Combined detection of Artemin and MMP 9 proteins may become a prognostic indicator [or gatric carcimoma and a potential new target of biolog- ical tumor therapy.

关 键 词：胃肿瘤 ARTEMIN 基质金属蛋白酶9 浸润 转移 

分 类 号：R735.2[医药卫生—肿瘤]