结直肠癌及肝和区域淋巴结转移灶CXCR4表达临床意义分析  

CXCR4 expression in colorectal cancer,liver and pericolic lymph-node metastases and its clinical significance

作　　者：张明亮[1] 郭伟[1] 许波[1] 田怀杲[1] 葛霞[2] 

机构地区：[1]蚌埠医学院第一附属医院肿瘤外科,安徽蚌埠233004 [2]蚌埠医学院第一附属医院病理科,安徽蚌埠233004

出　　处：《中华肿瘤防治杂志》2013年第4期292-295,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:观察CXCR4在结直肠癌及肝和区域淋巴结转移灶中的表达,分析其与结直肠癌临床病理因素的关系。方法:应用SP免疫组化方法检测48例结直肠癌组织、48例癌旁正常组织、15例肝转移灶和23例区域淋巴结转移灶中CX-CR4的表达。结果:48例癌组织中CXCR4表达占95.83%(46/48),弱阳性表达占16.67%(8/48),阳性表达占29.17%(14/48),强阳性表达占50.00%(24/48);48例癌旁正常组织中CXCR4的表达率为16.67%(8/48),均为弱阳性表达。CX-CR4在结直肠癌组织中的表达率(95.83%)明显高于癌旁正常组织(16.67%),χ2=72.38,P<0.01。在伴有肝和区域淋巴结转移的病例中,15例可切除肝转移标本中CXCR4的表达率为100.00%(15/15),其中阳性表达率为20.00%(3/15),强阳性表达率为80%(12/15);23例淋巴结转移标本中CXCR4的表达率为100.00%(23/23),阳性表达率为26.09%(6/23),强阳性表达率为73.91%(17/23)。CXCR4在转移灶中的表达率(100.00%,100.00%)与原发灶中的表达率(95.83%)差异无统计学意义,χ2=1.62,P>0.05;CXCR4高表达与结直肠癌患者的年龄、性别、部位、组织学类型及大体类型无关,P>0.05;而与肝(r=0.43,P<0.05)和区域淋巴结转移(r=0.53,P<0.05)呈正相关。结论:CXCR4在结直肠癌中的表达与肝和区域淋巴结转移呈正相关,检测癌组织CXCR4的表达有助于对结直肠癌患者预后的分析。OBJECTIVE： To observe the expressions of CXCR4 in colorectal cancer,liver and pericolic lymph-node metastasis specimens,and its relationship to clinicopathological characteristics. METHODS： Using SP immunohistochemi- cal method to detect the expression of CKCR4 in 48 colorectal cancer tissues,48 cases of normal tissues adjacent to cancer lesion,15 cases of liver metastases and 23 cases of pericolic lymph-node metastasis. RESULTS： CXCR4 expression was 95.83 % （46/48） in eolorectal cancer tissue, weakly positive expression was 16. 67 % （8/48）, positive expression was 29.17% （14/48）,strongly positive expression was 50% （24/48）;In normal tissues adjacent to cancer lesion, CXCR4 ex- pression was 16.67 %（8/48）, all of them were weak. The expression CXCR4 in colorectal cancer tissue（95.83 %） was ob- viously higher than that of normal tissue adjacent to cancer lesion（ 16.67 %（2 = 72.38, P〈0.01） ;In the liver and pericol- ic lymph-node metastasis cases, CXCR4 expression was 100.00 % （15/15） in hepatic resectable metastases tissues, positive expression was 20.00 % （ 3 / 15）, strongly positive expression was 80 % （ 12 / 15 ） ; in lymph-node resectable metastases tis- sues, CXCR4 expression was 100.00 % （23/23）, positive expression was 26.09 % （6/23）, strongly positive expression was 73.91% （ 17/23）, the expression of CXCR4 in metastases （ 100.00 0%, 100.00 0%） were not obvious different with the origi- nal tumor lesion（95.83 % ） ;The high expression of CXCR4 had no relationship with age, gender, site, histology and general type （P〈0.05） ;but was positive correlated with liver（r=0.43,P〈0.05） and pericolic lymph-node metastasis（r=0.53, P〈0.05）. CONCLUSION： The expression of ehemotactic factor CXCR4 in colorectal cancer is positive correlated with the liver and pericolic lymph-node metastasis,detecting the expression of CXCR4 in colorectal cancer tissue can contribute to the analysis of the prognosis of patients.

关 键 词：结直肠肿瘤 CXCR4 肝转移 区域淋巴结转移 

分 类 号：R735.34[医药卫生—肿瘤]