正常人群甲状腺功能与脂肪代谢的相关性分析  

The relationship between serum TSH(thyroid stimulating hormone) and lipid metabolism in euthyroid subjects

作　　者：张皎月[1] 陈璐璐[1] 孙晖[1] 郑涓[1] 胡祥[1] 王素星[1] 陈婷[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,武汉430022

出　　处：《中国糖尿病杂志》2013年第3期214-216,共3页Chinese Journal of Diabetes

基　　金：卫生部-默克雪兰诺中国甲状腺疾病教育;培训和流行病学调查;武汉市科技攻关计划项目(201161038340-02)

摘　　要：目的研究正常人群中血清促甲状腺激素(TSH)与脂肪代谢的关系。方法对武汉市1322名正常人群进行体格检查、血清TSH测定及肝脏超声检查。结果超重(A)组血清TSH水平高于对照(B)组。女性TSH>2.5mI U/L(B)组体重、BMI、WC、体脂含量高于TSH≤2.5mI U/L(A)组。体脂含量、BMI是TSH的独立影响因素。TSH不是影响非酒精性脂肪肝患病的独立危险因素。结论女性正常范围内的血清TSH与肥胖密切相关;血清TSH与非酒精性脂肪肝的患病风险无关。Objective To explore the relationship between serum TSH level and lipid metabolism in euthyroid subjects. Methods The 1322 subjects were enrolled in the trial. Physical, laboratory, and liver ultrasonography examinations were carried out for all of them. Results Serum TSH level was significantly higher in overweight （A）group than in control （B）group. Levels of body weight, BMI, waist circumference, and percentage of body fat were incr ：ased in TSH〉 2. 5 mI U/L women （B）group compared with those in TSH≤2. 5 mI U/L women （A）group. Percentage of body fat and BMI contributed significantly to the variance of TSH. TSH level was not the independent risk factor of non-alcoholic fatty liver disease. Conclusion Serum TSH in normal range is significantly correlated with obesity in women. And the change of TSH will not increase the prevalence of non-alcoholic fatty liver disease.

关 键 词：促甲状腺激素 肥胖 血脂 非酒精性脂肪肝 

分 类 号：R575.5[医药卫生—消化系统]