2型糖尿病患者微量白蛋白尿与大血管病变的相关性研究  

Correlation between microalbuminuria and macroangiopathy in T2DM patients

作　　者：韩佳琳[1] 董砚虎[2] 马山英[2] 孙士杰[3] 陈月华[4] 王娜[2] 

机构地区：[1]潍坊市中医院内分泌科,261031 [2]青岛内分泌糖尿病医院 [3]德州学院医学系 [4]江苏省苏北人民医院ICU

出　　处：《中国糖尿病杂志》2013年第3期249-251,共3页Chinese Journal of Diabetes

摘　　要：目的探讨T2DM患者微量白蛋白尿(MAU)与无临床症状大血管病变的相关关系。方法选取在我院住院和门诊随访的资料完整的糖尿病患者190例(DM组),正常对照组22名(NC组)。所有研究对象进行人体学测量、生化指标测定及胰岛素释放试验以及血管彩超检查颈总动脉内-中膜厚度(CIMT)和下肢动脉内径等。应用稳态模型评估法(HOMA)及李光伟指数(IAI)评价IR。结果 CI-MT与下肢各动脉内径均呈负相关。CIMT及下肢动脉内径与年龄、病程、SBP、DBP、TG、TC、LDL-C、HbA1c、MAU、HOMA-IR呈正相关,与HDL-C、IAI呈负相关,与BMI无相关性。结论 T2DM伴MAU患者同时存在早期大血管病变,而且MAU排泄率越高,早期大血管病变越重。IR可能是T2DM患者MAU和早期大血管病变共同患病的基础。Objective To investigate the correlation between microalbuminuria and rnacroangiopathy in T2DM patients without clinical symptoms. Methods One hundred and ninety in- and out-patients with diabetes from our hospital with complete data （DM group） and 22 healthy subjects （NC group） were involved in this observation. All subjects had oral glucose tolerance test （OGTT）, insulin release test, and vascular ultrasonography, and received examinations of height, weight, blood pressure, blood lipids, hemoglobin Aa c, microalbuminuria, carotid intima thickness （CIMT）, and lower limb artery internal diameter. Homeostasis model assessment （HOMA） and Li Guangwei＇s Index （IAI） were used to evaluate insulin resistance （IR）. Results CIMT was negatively related to internal diameter of lower limb＇s arteries. CIMT and internal diameter of lower limb＇s arteries were positively related to age, course of disease, SBP, DBP, TG, TC, LDL-C, HbA1c, MAU, and HOMA-IR, while negatively related to HDL-C and IAI, but without relation to BMI. Conclusion T2DM patients with microalbuminuria have macroangiopathy in the early stage of diabetes. The more albuminuria is, the severe macroangiopathy will be. Insulin resistance may be the common basis for microalbuminuria and macroangiopathy.

关 键 词：糖尿病 2型 微量白蛋白尿 大血管病变 

分 类 号：R587.2[医药卫生—内分泌]