5-脂氧合酶(5-LOX)及代谢产物在异氟醚预处理脑保护作用中的研究进展  

Research Progress of the Role of 5-lipoxygenase and its Metabolites on Isoflurance Preconditioning Induced Cerebral Protection

作　　者：吕海港[1] 任鹏程[1] 高昌俊[1] 孙美艳[1] 赵晓勇[1] 柴伟[1] 孙绪德[1] 

机构地区：[1]第四军医大学唐都医院麻醉科,陕西西安710038

出　　处：《现代生物医学进展》2013年第3期555-557,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30972833;81271343)

摘　　要：缺血性脑血管疾病(Ischemia Cerebral Vascular Disease,ICVD)可造成不同程度的神经功能障碍,以其高发病率、高致残率、高复发率、高死亡率严重威胁着人们的身体健康。而脑组织缺血后再灌注损伤即脑缺血再灌注损伤(ischemia-reperfusion injury)是脑缺血性疾病的最主要的损伤原因之一,因此阐明脑缺血再灌注损伤发生发展的病理生理机制、探寻有效的预防保护措施成为当今研究的重点问题。本文回顾、归纳脑缺血再灌注损伤的相关分子机制及异氟醚预处理对脑缺血再灌注损伤的保护作用,分析5-脂氧合酶及其代谢产物在脑缺血再灌注损伤中的作用及其与其他分子的相互关系,旨在探讨5-脂氧合酶及其代谢产物在异氟醚预处理保护脑缺血再灌注损伤中可能起到的作用。为脑缺血再灌注损伤的防治提供更多的理论依据。Ischemic cerebrovascular disease （ICVD） can cause varying degrees of neurological dysfunction, threaten to the physical health of people. Ischemia-reperfusion injury is one of the major damage causes of cerebral ischemic diseases. Therefore, to clarify the pathophysiological mechanisms of development of cerebral ischemia-reperfusion injury as well as the prevention and control measure have become recent research focus. This article will review and induce the molecular mechanism related to ischemia-reperfusion injury and the protective effect ofisoflurane preconditioning in cerebral ischemia-reperfusion injury analyze the effect of the 5-LOX and its metabolites on cerebral ischemia-reperfusion injury as well as their interaction with other molecules, explore the possible role of 5-LOX and its metabolites in the effect of isoflurane preconditioning on cerebral ischemia-reperfusion injury. The aim is to investigate the possible role of 5-LOX and its metabolites in cerebral ischemia-reperfusion injury and provide more theory for prevention and control of cerebral ischemia-reperfusion injury.

关 键 词：缺血再灌注损伤 异氟醚 5-脂氧合酶 TOLL样受体 

分 类 号：R743.34[医药卫生—神经病学与精神病学]