数字连接实验和数字符号实验联合应用诊断轻微肝性脑病价值研究  

Significance of number connection test and digit symbol tests for the diagnosis of minimal hepatic encephalopathy

作　　者：翟慧勤[1] 范红[1] 寻琳婷[1] 王芸[1] 

机构地区：[1]昆明医科大学云南省第一人民医院消化科,昆明650032

出　　处：《中国实用内科杂志》2013年第3期217-219,共3页Chinese Journal of Practical Internal Medicine

基　　金：国家自然科学基金资助(81260077)

摘　　要：目的探讨数字连接实验(NCT)和数字符号实验(DST)诊断轻微肝性脑病的应用价值。方法以2011年10月至2012年4月云南省第一人民医院消化科收治的65例乙肝肝硬化患者为病例组,选择至少接受12年以上教育的健康志愿者90例作对照,两组均采用NCT-A、DST进行检测。以NCT-A大于正常对照两个标准差为异常,DST小于正常对照两个标准差为异常。结果随着年龄的增加NCT值升高,DST值下降。NCT-A、DST两项均异常者38例,其中男22例,女16例;年龄21～69岁,平均(52.7±11.8)岁。NCT-A时间随着患者Child肝功能分级的严重程度增加而延长(P<0.05),DST得分随着患者Child肝功能分级严重程度而降低(P<0.05)。结论 NCT-A、DST联合用于检测MHE,简便易行,对减少MHE的漏诊、误诊具有较大作用,从经济学的角度考虑其价格低廉,特别适用于门诊筛查MHE患者及肝硬化并发MHE患者住院治疗后的远期追踪观察。Objective To explore the significance of number connection test （NCT） and digit symbol test （DST） for the diagnosis of minimal hepatic encephalopathy （MHE）. Methods A total of 65 patients with hepatitis B-associated cirrhosis were recruited from the department of gastroenterology, the First People＇s Hospital of Yunnan Province. We also enrolled ninety healthy volunteers with an educational background for 〉 12 years as normal controls. The NCT-A and DST were employed for assessment. Results The diagnostic yield for the combination of NCT-A and DST was 46% （30/65）. Prolonged duration of NCT-A was linked to the increasing severity of Child-Pugh stages （ P 〈 0.05 ）, which was associated with progressively reduced DST score （P 〈 0. 05）. Conclusion Featured by high feasibility and convenience, the combination of NCT-A and DST is useful to the diagnosis of MHE and may reduce the rates for misdiagnosis and underdiagnosis. In view of high cost-effectiveness, the combination may be particularly suitable for out-patient screening and long-term follow-up investigation following patients＇ discharge from the hospital.

关 键 词：轻微肝性脑病 数字连接实验 数字符号实验 

分 类 号：R575[医药卫生—消化系统]