大黄煎剂保留灌肠治疗轻微肝性脑病临床研究  

Clinical Observation on Rhubarb Decoction Retention Enema in Treatment of Minimal Hepatic Encephalopathy

作　　者：姚春[1] 姚凡[1] 谢武[1] 何燕[1] 韦玉仙[1] 付蕾[2] 

机构地区：[1]广西中医药大学院第一附属医院,广西南宁530001 [2]广西中医药大学附属瑞康医院,广西南宁530001

出　　处：《辽宁中医杂志》2013年第3期474-476,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然基金项目(81160439)

摘　　要：目的:观察大黄煎剂保留灌肠对轻微肝性脑病患者内毒素、血氨及数字连接试验(NCT)、肝功能的影响。方法:共选取80例乙肝肝硬化并发轻微肝性脑病患者,随机分为空白对照组(A组)、中药组(B组)、乳果糖组(C组)、安慰剂组(D组),每组各20例,4组均采用基础治疗,B、C、D组在基础治疗的基础上分别加用大黄煎剂(大黄、乌梅)、乳果糖、安慰剂保留灌肠。结果:中药组在降低内毒素、血氨、NCT及改善肝功能方面均优于其他3组(P<0.01)。结论:大黄煎剂保留灌肠治疗轻微肝性脑病安全、有效。Objective ：To observe the retention enema with Rhubarb decoction in the treatment of minimal hepatic encephalopa- thy in patients with cirrhosis endotoxin, blood ammonia and number connection test （NCT） , and liver function. Methods：A total of 80 cases of liver cirrhosis complicated with minimal hepatic encephalopathy were randomly divided into control group （group A） , Chinese medicine group （ group B） , laetulose group （ group C ） , the placebo group （ D group） , 20 cases in each group. The 4 groups were given tile basic treatment, besides, B, C and D groups were treated with retention enema by Rhubarb decoction,lactulose, pla- cebo respectively. Results ：Traditional Chinese medicine group was better than the other three groups in the reduction of endotoxin, blood ammonia, NCT and improvement of hepatic function （P 〈 0.01 ）. Conclusion：Rhubarb decoction retention enema in the treatment of minimal hepatic encephalopathy is safe and effective.

关 键 词：大黄煎剂 保留灌肠 轻微肝性脑病 

分 类 号：R749.9[医药卫生—神经病学与精神病学]