一氯三嗪-β-环糊精包合晚香玉香精纳米粒的制备及表征  

Preparation and Characterization of Tuberose Fragrance-loaded MCT-β-CD Nanoparticles

作　　者：张佳[1] 肖作兵[1] 胡静[1] 周如隽[1] 李百川[1] 

机构地区：[1]上海应用技术学院香料香精技术与工程学院,上海201418

出　　处：《精细化工》2013年第3期308-312,319,共6页Fine Chemicals

基　　金：国家十二五支撑计划(2009CB226104);国家自然科学基金(21076125&21276157);上海市"登山计划"国际合作项目(11290707600)~~

摘　　要：以一氯三嗪-β-环糊精(MCT-β-CD)为壁材,晚香玉香精为芯材,通过包合法制备一氯三嗪-β-环糊精晚香玉香精纳米粒。研究了壁材与芯材的质量比、乙醇与水的体积比、反应时间、反应温度、搅拌速度对晚香玉香精纳米粒粒径的影响,并采用动态激光光散射仪(DLS)、透射电镜(TEM)、红外光谱(IR)及热重分析仪(TGA)对其结构及性能进行了表征。结果表明:在V(乙醇)∶V(水)=1∶0.67,m(香精)∶m(壁材)=1∶15,反应时间10 h,搅拌速度1 300 r/min,温度为35℃的条件下制备的晚香玉香精一氯三嗪-β-环糊精纳米粒的粒径为216.4 nm,粒径分布系数(PDI)为0.221,香精装载量达17.2%,能减缓高温下香精的释放速率。Tuberose fragrance loaded monochlorotriazinyl-β-cyclodextrin （ MCT-β-CD ） nanoparticles were prepared by the inclusion complexation method. The effects of the volume ratio of ethanol to water,the mass ratio of tuberose to MCT-β-CD, the reaction time, the stirring rate and the reaction temperature on the size distribution of tuberose fragrance-loaded MCT-β-CD nanoparticles were investigated. The tuberose fragrance-loaded MCT-β-CD were characterized by means of dynamic light scattering （ DLS ） , transmission electron microscope （ TEM ） , infrared spectrometer （ IR ） and thermogravimetric analyzer （TGA）. The results show that the particle size was 216.4 nm, the polydispersity index （PDI） was 0. 221 and the fragrance loading capacity was 17.2% when V （CH3CH2OH）：V（H20） = 1：0.67,m（fragrance）：re（wall materials） = 1：15,reaction time was 10 h, rotational speed was 1 300 r/min and reaction temperature was 35 ℃. The release rate of tuberose fragrance-loaded MCT-β-CD nanoparticles was decreased under high temperatures.

关 键 词：晚香玉香精 包合法 纳米粒 一氯三嗪-β-环糊精 

分 类 号：TQ657.9[化学工程—精细化工]