肺癌核素显像与Pgp、PCNA、GST-π关系的初步研究  

PRIMARY STUDY OF RELATION BETWEEN LUNG CANCER RADIONCULIDE TOMOGRAPHY AND Pgp,CNA, GST-π

作　　者：严建[1] 蔡瑾[1] 陆喆[1] 徐建勋[1] 周云生[1] 王维良 

机构地区：[1]上海市徐汇区中心医院,200031

出　　处：《中国现代医学杂志》2000年第6期16-16,19,共2页China Journal of Modern Medicine

摘　　要：目的 :探讨肺癌核素显像99mTc-MIBI滞留分数与P糖蛋白 (Pgp)、增殖细胞核抗原 (PCNA)和胎盘型谷胱甘肽 -S -转移酶 (GST -π)的关系。方法 :12例肺癌病人术前分别作肺部早期和延迟99mTc -MIBI断层显像 ,计算肿瘤部位99mTc -MIBI滞留分数 ,与手术后肿瘤标本测定的Pgp、PCNA、GST -π水平作相关分析。结果 :99mTc-MIBI滞留分数与Pgp明显负相关 (r =- 0 .771P <0 .0 1) ,而与PCNA、GST -π无显著意义的相关关系。结论 :99mTc -MIBI滞留分数可能较好预测Pgp的水平 。Objective: To detect relation between retention index of technetium-99m-MIBI in lung cancer radionuclide tomography and pglycoprotein (Pgp); proliferating cell nuclear antigen (PCNA); glutathione S-transferase-π (GST-π). Methods: 12 patients with lung cancer received ling tomography at 30min and 120min after intravenously injected technetium-99m-MIBI. Retention index in the region of tumor was then calculated, and correlation between the retention index and Pgp, PCNA, GST-πwere been analyzed. Results: There was inverse correlation between the retention index and Pgp (r=-0.771 p<0.01), but no significant correlation with PCNA, GST-π. Conclusions: The retention index of technetium-99m-MIBI in the tumor areas may be used as a functional parameter for the Pgp level, and has the good prognostic value in the lung cancer multidrug-resistant.

关 键 词：肺癌 核素显像 P糖蛋白 增殖细胞核抗原 

分 类 号：R734.2[医药卫生—肿瘤]