溶血磷脂酸受体2  

Research progress on lysophosphatidic acid receptor 2

作　　者：龚晓华[1] 饶勇[1] 马卫列[1] 张志珍[1] 

机构地区：[1]广东医学院生物化学与分子生物学教研室,东莞523808

出　　处：《生命的化学》2013年第1期24-28,共5页Chemistry of Life

基　　金：广东省自然科学基金项目(S2011010002984);广东省科技计划项目(2012B031800426)

摘　　要：溶血磷脂酸受体2(lysophosphatidic acid receptor 2,LPA2),也称内皮分化基因受体4(endothelial differentiation gene receptor 4,EDG4),是溶血磷脂酸G蛋白偶联受体类的一种,对溶血磷脂酸有较高亲和力,可介导多种细胞活动。近年研究发现,LPA2/EDG4在卵巢癌细胞中过表达,同时与乳腺癌、结直肠癌、动脉粥样硬化、呼吸道疾病、妊娠性高血压等有着密切关系。Lysophosphatidic acid receptor 2 （LPA2）, also known as endothelial differentiation gene receptor 4 （EDG4）, is a G-protein coupled receptor （GPCR） activated by lysophosphatidic acid. It has high affinity to lysophosphatidic acid, and can mediate many kinds of cellular activities. Recent researches have shown that LPA2/EDG4 is overexpressed in ovarian cancer cells. In addition, it is closely connected with breast carcinoma, colon cancer, atherosclerosis, respiratory disease and hypertensivedisorder complicating pregnancy

关 键 词：溶血磷脂酸 溶血磷脂酸受体2 内皮分化基因受体4 

分 类 号：R363[医药卫生—病理学]