前列腺癌潜在的标志物PAGE4/CT16.7  

PAGE4/CT16.7:a potential marker for prostate cancer

作　　者：谢莎[1] 肖燕子[2] 张庆梅[1] 谢小薰[1] 

机构地区：[1]广西医科大学基础医学院,南宁530021 [2]哈尔滨医科大学公共卫生学院,哈尔滨150081

出　　处：《生命的化学》2013年第1期73-76,共4页Chemistry of Life

基　　金：国家自然科学基金项目(30760055;81060207);广西高发疾病研究创新性团队基金项目(桂教人[2007]71号);广西自然科学基金项目(2011GXNSFA018275);广西教育厅研究生教育创新计划项目(2011105981002M192)

摘　　要：前列腺癌相关基因4(prostate-associated gene 4,PAGE4)是癌-睾丸抗原家族成员之一,具有在生殖系统组织中表达,而在非生殖系统组织中几乎不表达的特性。目前已发现前列腺癌患者可引起PAGE4的细胞免疫反应,前列腺炎患者血清中可检测到PAGE4蛋白。因此PAGE4有望成为前列腺癌免疫治疗潜在靶点及前列腺疾病筛查的又一新的血清标志物。对PAGE4基因及蛋白质的结构特点、表达特性、抗原肽筛选和生物学功能等方面进行综述。PAGE4 （prostate-associated gene 4） is a member of cancer-testis antigen family, which is expressed in reproductive tissues, but is restrictively expressed in non-reproductive tissues. It has been demonstrated that the patients with prostate cancer could cause cell immunity against PAGE4. PAGE4 protein could be detected in sera from the prostatitis patients. Therefore, PAGE4 could become a potential target for prostate cancer immunotherapy and a new serum maker for screening prostate-related diseases. The gene structure, protein feature, expressive profile, screening of antigenic peptides and biological function of PAGE4 were reviewed bellowed.

关 键 词：PAGE4 前列腺 肿瘤免疫治疗 

分 类 号：R737.25[医药卫生—肿瘤]