含肟酯类姜黄素衍生物的合成及其抑菌活性研究  

Synthesis and antifungal activities of oxime-esters of curcumin derivatives

作　　者：薛伟[1] 龚华玉[1] 仇秋娟[1] 赵洪菊[1] 李海畅[1] 韩菲菲[1] 夏丽娟[1] 

机构地区：[1]绿色农药与农业生物工程国家重点实验室培育基地教育部绿色农药与生物工程重点实验室,贵州大学精细化工研究开发中心,贵州贵阳550025

出　　处：《化学试剂》2013年第3期201-205,208,共6页Chemical Reagents

基　　金：国家十二五科技支撑计划资助项目(2011BAE-06B04-09)

摘　　要：将肟酯引入单羰基姜黄素衍生物1,5-二取代芳基-1,4-戊二烯-3-酮化合物中,通过醚化、肟化、酰化,最后酯化合成11个不对称1,5-二取代-1,4-戊二烯-3-酮肟酯类姜黄素衍生物,其结构经IR、1HNMR、13CNMR和元素分析确证。初步生物活性测试结果表明,部分化合物具有一定的抑菌活性。Curcumin was modified by active functional group oxime ester with biologically active factor splicing of 1,5-diphenyl-1,4-pentadien-3-one compound. Eleven novel com-pounds were synthesized via etherification, oximic reaction and esterify reaction. The structure was identified by IR, 1HNMR,13 CNMR and element analysis. The preliminary bioassay indicated that some of the compounds exhibited good antifungal activity against Fusarium graminearum, Fusarium oxysporum and Cytospora mandshurica.

关 键 词：姜黄素 肟酯 合成 抑菌活性 

分 类 号：O625.1[理学—有机化学]