肠上皮间淋巴细胞在炎症性肠病中的免疫调节效应  

Immunoregulatory effects of intraepithelial lymphocytes in inflammatory bowel disease

作　　者：吴维[1] 邱骅婧[1] 刘占举[1] 

机构地区：[1]同济大学附属第十人民医院消化内科,上海市200072

出　　处：《世界华人消化杂志》2013年第7期568-573,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81270470;No.81061120521~~

摘　　要：上皮细胞间淋巴细胞(intraepithelial lymphocyte,IEL)广泛分布在肠道、呼吸道、生殖道等黏膜组织中.肠道IEL定位于肠道的上皮细胞与基底膜之间.正常成人的小肠组织中,每4-10个肠上皮细胞(intestinal epithelial cell,IEC)存在1个IEL,大肠组织中可能略少.作为肠道中对抗外界感染的第一道屏障,IEL在维持上皮细胞的完整性、免疫监视、加强和调节免疫应答及维持肠道稳态等方面发挥了重要作用.研究发现,IEL在炎症性肠病的发病机制中也具有一定地位.Intraepithelial lymphocytes （IELs） are found in a wide variety of sites, especially in the mucosa of the intestine, respiratory tract, and genital tract. Intestinal IELs are located between intestinal ep- ithelial cells （IECs） and the basement membrane. The ratio between IECs and IELs in the small intestine is 4-10 ： 1, but is slightly lower in the large intestine. As the first guard of the intestine, IELs play a significant role in maintaining the in- tegrity of the mucosa, immune surveillance and regulating the homeostasis on the intestinal mu- cosal surface. Recent studies have demonstrated that IELs are also involved in the pathogenesis of inflammatory bowel disease （IBD）.

关 键 词：肠上皮间淋巴细胞 炎症性肠病 细胞毒活性 黏膜免疫 

分 类 号：R574[医药卫生—消化系统]