热休克蛋白27在常见消化道癌及癌前病变中的表达及意义  

Expressions and Significance of Heat Shock Protein 27 in Carcinoma and Precancerous Lesion of Frequent Digestive Tract

作　　者：吴永梅[1] 居来提[1] 靳瑜[2] 邱枫[3] 王君[1] 苟冬梅[1] 吴英杰[1] 

机构地区：[1]新疆医科大学第五附属医院,新疆乌鲁木齐830011 [2]新疆医科大学第六附属医院,新疆乌鲁木齐830002 [3]新疆医科大学第二附属医院,新疆乌鲁木齐830063

出　　处：《新疆医学》2012年第12期18-22,共5页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区自然科学基金项目(200821139);新疆维吾尔自治区科技支疆项目(200991127)

摘　　要：目的:检测热休克蛋白27(heat shock proteins,HSPs)在人常见消化道癌及癌前病变中的表达情况,探讨其在消化道癌诊断中的作用及其意义。方法:采用免疫组化SABC方法检测HSP27在Barrett食管(Barrett'esophageal)、食管贲门部腺癌(Adenocarcinoma ofthe esophagus and Cardia)、浅表性胃炎、慢性萎缩性胃炎伴高级别上皮内瘤变(CAG and H-IN)、胃窦腺癌、结肠息肉(Colonic polyps)、结肠腺癌(Colonic adenocarcinoma)组织中表达.结果HSP27阳性表达率在Barrett食管68.2%、食管贲门部腺癌91.7%(P<0.05);浅表性胃炎17.9%(P<0.05)、CAG and H-IN47.1%、胃癌组织中的阳性率分别为90%(P<0.05);结肠息肉84%、结肠腺癌96%(P<0.05)。结论:HSP27与肿瘤的发生有关,可作为消化道肿瘤诊断、判断预后和指导治疗提供理论依据。Objective ：To detect the expression of heat shock protein 27 in carcinoma and precancerous le sion of frequent digestive tract and investigate the roles of HSPs. Methods lmmunohistochemical technique, SABC method,as used to examine the expression of HSP27 in gastric carcinoma and gastritis mucosa. Results HSP27 was detected in 68.2 % of Barrettsophagcd, in 91. 7 % of Adenocarcinoma of the esophagus and Cardia, in 17.9% of gastric epithelia,47.1% of dysplasia,90% of gastric carcinoma,in 84% of Colonic polyps, in 96% of Colonic mechanism of HSP27 action could help to provide theoretical basis for the biological therapy of gastric cancer

关 键 词：热休克蛋白27 消化道 癌前病变 癌 

分 类 号：R363.27[医药卫生—病理学]