阿尔茨海默病患者和健康老年人血清Aβ水平的变化及临床意义  

Alzheimer＇s disease and healthy elderly people serum β-amyloid protein variable and its clinical significance

作　　者：郝建华[1] 何亮[1] 张庆侠[1] 张然蓉[1] 冯静霞[1] 谢岭平[1] 

机构地区：[1]广东医学院附属南山人民医院检验科,深圳市518052

出　　处：《实用检验医师杂志》2012年第4期207-210,共4页Chinese Journal of Clinical Pathologist

基　　金：广东省深圳市南山科技局项目（2012005）

摘　　要：目的探讨阿尔茨海默病（Alzheimer’s disease，AD）患者和健康老年人血清中B淀粉样蛋白（Bamyloid protein，AB）水平在正常衰老和AD进程中的变化规律及临床意义。方法采用酶联免疫吸附法检测63例AD患者（AD组）和206例健康老年人（健康对照组）血清中Aβ水平，并分析其与AD的关系。结果AD组和健康对照组不同性别组间血清AB水平差异均无统计学意义（P均〉0．05）；健康对照组不同年龄段组间At3水平差异均无统计学意义（P均〉0．05）；轻度AD组血清Aβ42水平较中度及以上AD组和健康对照A组均显著升高，差异均有统计学意义（P均〈0．01），中度及以上AD组Aβ42血清水平随病情的加重而下降，与健康对照A组比较差异无统计学意义（尸〉0．05）；AD各组A1340血清水平与健康对照A组比较差异无统计学意义（P〉0．05）。结论AD患者血清中Aβ水平，尤其是Aβ42水平的变化，可作为辅助诊断早期老年性AD的血清生物学标志物。Objective To study the healthy elderly people and Alzheimer% disease （AD） patients serum 13-amyloid protein levels during normal aging and the natural coupe of AD, and their clinical values for AD diagnosis. Methods Enzyme linked immunosorbeut assay was employed to measure serum Aβ levels of 63 AD cases （AD group） and 206 healthy elderly people （healthy control group）. The relation of AD and serum Aβ levels were analysed. Results All Aβ variables in age were unchanged in AD group and healthy control group （Pall〉 0.05）, and also in sex were unchanged in healthy control group（Pall〉 0.05）. Levels of AI342 in the mild AD group were higher than in moderate or above AD group and healthy control A group, and the differences all had statistical significance （Pall〈 0.01 ）. Level of Aβ42 was similar between moderate or above AD group and healthy control A group （P〉 0.05）. AD patients had elevated serum AJ340, but there was no statistically significant difference as compared with healthy control A group （P〉 0.05）. Conclusion AD serum Aβ levels, especially Aβ42, may be a useful biomarkers for AD diagnosis.

关 键 词：阿尔茨海默病 健康老年人 Aβ淀粉样蛋白 酶联免疫吸附法 

分 类 号：R749.16[医药卫生—神经病学与精神病学]