急性早幼粒细胞白血病诊断和治疗期间的细胞形态观察  

Observation of cell morphous on acute promyelocytic leukemia during diagnosis and therapy stages

作　　者：吴侠[1] 张时民[2] 张红娟[1] 

机构地区：[1]秦皇岛市第一医院检验科,秦皇岛市066000 [2]中国医学科学院北京协和医学院北京协和医院检验科,北京市100730

出　　处：《实用检验医师杂志》2012年第4期239-242,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的探讨细胞形态学检验在急性早幼粒细胞白血病（acute promyelocytic leukemia，APL）诊断和治疗中的应用。方法APL患者骨髓及外周血细胞通过瑞一姬染色进行形态学观察．检测其治疗过程中细胞形态的变化。结果治疗初期，APL患者外周血WBC逐渐升高，第12天达到最高峰，应用药物治疗后，WBC逐渐下降。应用亚砷酸治疗一个疗程，连续监测APL患者的骨髓象和血象变化，患者疾病仍未完全缓解。一个月后，继续治疗一个疗程，患者疾病完全缓解。结论APL治疗过程中，细胞形态的观察对亚砷酸疗效的判定及对疾病缓解或恶化监测有一定帮助。Objective To explore the diagnosis and therapy of cell morphology inspection to acute promyelocytie leukemia （APL） patients. Methods Marrow and peripheral blood cells from APL patients were performed morphology observation after Wright-Giemsa staining. And the ceU morphological change in treatment were monitored. Results The peripheral WBC of APL patients were gradually raised in the early treatment, and the maximum value was appeared in the twelfth day. After drug treatment, WBC decline gradually. Application of arsenious acid therapy for a peiod of treatment, the continuous monitoring of APL patients with bone marrow and blood cells smear change, the disease was still not completely remission. Continue to treat a period of treatment after a month, patient＇s disease was completely remission. Conclusion During process of APL patients treatment, cells morphology observation aids in judgment of arsenious acid treatment and the dis- ease remission or aggravation.

关 键 词：急性早幼粒细胞白血病 细胞形态学 治疗 亚砷酸 

分 类 号：R733.71[医药卫生—肿瘤]