基因foxl2的结构及表达调控  

Structure and Expression Regulation of Gene foxl2

作　　者：刘晓玲[1,2] 刘建国[1] 张志峰[1] 

机构地区：[1]中国海洋大学海洋生物遗传育种教育部重点实验室,山东青岛266003 [2]烟台大学生命科学学院,山东烟台264005

出　　处：《中国海洋大学学报（自然科学版）》2013年第3期38-43,共6页Periodical of Ocean University of China

基　　金：山东省自然科学重点基金项目(Z2008D02);国家自然科学青年基金项目(30901097)资助

摘　　要：叉头框转录因子L2基因(foxl2)是参与多个靶基因转录调控的重要转录因子基因。目前研究认为该基因主要参与脊椎动物的卵巢分化、发育及其功能维持,但在无脊椎动物中的研究很少。本文结合作者已有的研究成果概述了foxl2基因结构特点,提出该亚家族主要以叉头框的6个特殊氨基酸序列与其它亚家族区分开来;总结了该基因自身的表达调控,认为可能在转录、转录后及翻译后等不同水平都存在调控;进一步对该基因在不同动物中的空间表达特征及功能等方面进行概述,推测foxl2基因在低等动物中具有的表达多样性可能与其功能多样性有关。Forkhead box transcripition factor L2 gene （foxl2） encodes an important transcription factor involving in transcripitional regulation of a set of target genes, playing a crucial role in the differentiation, development and function maintenance of vertebrtate ovary as evidenced by earlier findings. However, studies on its structure and function in invertebrate are scarce, In this review, we summarized the struc-tural characteristics of foxl2, proposing that foxl2-representing subfamily was different from other sub-families in 6 specific amino acids in forkhead box. We outlined the expression regulation of foxl2 ; believ- ing that its expression could be regulated either during transcriptiona, or after transcription or after trans-lationa. We also reviewed the spatial expression characteristics of the gene and its functions in diverse ani-mals; inferring that foxl2 expressed in lower animals in diverse patterns, which should imply its diverse functions in these animals.

关 键 词：FOXL2 表达调控 功能 性别 

分 类 号：Q291[生物学—细胞生物学]