血清血管生长因子浓度变化与急性脑梗死后神经功能康复的关系  

Relationship between serum concentration of vascular growth factor and neurological recovery in patients with acute cerebral infarction

作　　者：官俏兵[1] 张晓玲[1] 王琰萍[1] 余波[1] 杜瑛媛[1] 万里红[1] 

机构地区：[1]嘉兴医学院附属第二医院,314000

出　　处：《实用医学杂志》2013年第5期726-728,共3页The Journal of Practical Medicine

基　　金：浙江省嘉兴市科技局资助项目(编号:2010AY1038)

摘　　要：目的:研究血清血管生长因子浓度变化与急性脑梗死后神经功能康复的关系。方法:测定60例急性脑梗死患者发病后不同时间点的血清血小板衍生内皮细胞生长因子(PD-ECGF)与血管内皮生长因子(VEGF)浓度,同步评估美国国立卫生研究院脑卒中量表(NIHSS)评分,并记录脑梗死的体积。另选取同期健康体检人员(否认有高血压病、糖尿病、心、脑血管病等病史)30例作为对照组。结果:脑梗死患者发病后24h内和第3、7、14天的平均血清PD-ECGF及VEGF浓度均高于相应对照组,并以发病后第7天最高,第14天最低。相应时间点的NIHSS评分差异无统计学意义(F=1.925,P=0.126)。不同时间点的血清PD-ECGF及VEGF浓度与NIHSS评分无相关性,与脑梗死体积也无相关性。结论:血清PD-ECGF、VEGF浓度在脑梗死后即有升高,参与新生血管形成及脑神经功能恢复,但血清浓度高低并非短期神经功能康复程度和预后的决定因素。Objective To explore the relationship between serum concentration of vascular growth factor and neurological recovery, in patients with acute cerebral infarction （ACI）. Methods Serum concentrations of platelet-derived endothelial cell growth factor （PD-ECGF） and vascular endothelial growth factor （VEGF） in 60 patients with ACI were measured, and the scores of national institutes of health stroke scale （NIHSS） were measured at different time points after stroke. Moreover, volumes of infarction at admission were recorded. Results Serum concentrations of PD-ECGF and VEGF in 24 hours and on day 3, 7; 14 in ACI group were significantly higher than those in control group, and reached the peak on day 7 and the trough on day 14. The differences of NIHSS scores at corresponding time points were statistically insignificant （F = 1.925, P = 0.126）. The serum concentrations of PD-ECGF and VEGF were irrelevant to NIHSS scores or cerebral infarction volumes at any time point. Conclusions Serum concentrations of PD-ECGF and VEGF were increased after the occurrence of infarction, which may take part in the angiogenesis and neurological recovery. However, the levels did not determine the degree of neurological impairment or the rehabilitation in short time.

关 键 词：脑梗死 血小板衍生内皮细胞生长因子 血管内皮生长因子 美国国立卫生研究院卒中量表 

分 类 号：R743.3[医药卫生—神经病学与精神病学]