^60Co-γ射线辐射灭菌方法对栓塞用微胶囊材料稳定性的研究  

Effect of ^(60)Co-γ irradiation sterilization on the stability of alginate/chitosan microcapsules

作　　者：郑佳妮[1,2] 谢红国[1] 于炜婷[1] 刘袖洞[3] 谢威扬[1] 马小军[1] 

机构地区：[1]中国科学院大连化学物理研究所生物医用材料工程组,辽宁大连116023 [2]中国科学院研究生院,北京100049 [3]大连大学环境与化学工程学院,辽宁大连116622

出　　处：《功能材料》2013年第5期645-648,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(10979050,51103157)

摘　　要：利用60Co-γ射线辐射方法,对栓塞用海藻酸钠/壳聚糖/海藻酸钠(ACA)微胶囊进行灭菌研究,考察了辐射灭菌对微胶囊稳定性,包括形态、机械强度、材料结构以及材料降解情况的影响。分别利用激光粒度仪、球磨法、傅里叶红外光谱仪以及乌氏粘度法和锥板粘度计测定了辐射灭菌前后微胶囊的粒径、强度、结构以及壳聚糖分子量和海藻酸钠粘度的变化。结果表明,经过60Co-γ射线辐射灭菌后,ACA微胶囊颜色变深呈黄色,ACA微胶囊略有膨胀,且破碎率升高强度下降,由于辐射引发的自由基反应,海藻酸钠和壳聚糖的分子结构中有双键生成,并且壳聚糖和海藻酸钠材料均发生降解而使分子量降低粘度下降,辐射灭菌的降解作用随壳聚糖分子量的增大而增强。Alginate/chitosan/alginate （ACA） microcapsules were sterilized by ^60Co-γ irradiation. The stability of ACA microcapsules including morphology, mechanical strength,material composition and degradation was fully investigated. The changes of color, particle size, mechanical strength, composition and molecular weight of ACA microcapsule materials were studied by laser particle sizer, bead grinding method, Fourier transform in- frared （FT-IR） spectrometer, and Ubbelohde and cone-plate viscometer, respectively. The results indicated that the color of ACA microcapsules became yellow. ACA microcapsules swelled and the fragment increased af- ter irradiation. The mechanical strength of ACA microcapsules decreased due to degradation of materials, and double bond generated because of the free radical reaction. Both molecular weight of chitosan and the apparent viscosity of alginate decreased significantly after ^60Co-γ irradiation. Moreover, the degradation effect increased with the molecular weight of chitosan. Decrease of irradiation dosage and enhancement of mechanical strength are possible ways to realize ^60Co-γ irradiation sterilization.

关 键 词：60Co-γ射线辐射灭菌 微胶囊 稳定性 机械强度 降解 

分 类 号：O63[理学—高分子化学]