血清和尿液中MMP-9水平的检测在卵巢癌诊断中的意义  

Clinical significance of serum and urine MMP-9 in patients with ovarian cancer

作　　者：梁彬[1] 郭政东[1] 李云慧 

机构地区：[1]中国医科大学高等职业技术学院检验教研室,沈阳市110001 [2]沈阳军区202医院检验科

出　　处：《中国肿瘤临床》2013年第5期287-289,共3页Chinese Journal of Clinical Oncology

基　　金：辽宁省科技厅自然科学基金(编号:201102279)资助~~

摘　　要：目的:探讨血清与尿液中MMP-9检测在卵巢癌诊断中的意义。方法:选取59例卵巢癌患者(恶性组),52例卵巢良性肿瘤患者(良性组)和40例健康体检妇女(正常对照组)为研究对象。用ELISA方法测定血清和尿液中MMP-9的水平。结果:恶性组血清和尿液中MMP-9的水平明显高于良性组和正常对照组,差异有统计学意义(P<0.01)。良性组血清和尿液中MMP-9水平与正常对照组差异无统计学意义(P>0.05)。血清与尿液中MMP-9的ROC曲线下面积分别为0.831和0.794(P<0.01)。血清MMP-9和CA125的联合诊断达到最高的灵敏度93.5%和特异度94.8%。结论:MMP-9可能与卵巢癌的发生和发展有关,血清与尿液中MMP-9的检测可以用于卵巢癌的辅助诊断。Objective： This study evaluates the serum and urine matrix metalloproteinase-9 （MMP-9） for the diagnosis of ovarian cancer. Methods： A total of 59 patients with ovarian cancer, 52 patients with benign ovarian tumor, and 40 healthy controls were recruited in this study. The serum and urine levels of MMP-9 were measured by enzyme-linked immunosorbent assay methods. Results： The serum and urine levels of MMP-9 in the malignant group were significantly higher than those in the benign and healthy control groups （P 〈 0.01）. Consequently, the serum and urine levels of MMP-9 in the benign group were similar with those of the healthy control group （P 〉 0.05）. The receiver operating characteristic curves of serum and urine MMP-9 were 0.831 and 0.794, respectively. The combined detection of serum MMP-9 and cancer antigen 125 reached a high sensitivity of 93.5% and a specificity of 94.8%. Conclusion： MMP-9 may be closely associated with the progression of ovarian cancer. Serum and urine MMP-9 may be helpful in the diagnosis of ovarian cancer.

关 键 词：卵巢癌 基质金属蛋白酶-9 血清 诊断 

分 类 号：R737.31[医药卫生—肿瘤]