Th17细胞与肿瘤微环境关系的研究进展  

Correlation between Th17 cells and tumor microenvironment

作　　者：齐文慧[1] 黄小娟[1] 王俊艳[1] 

机构地区：[1]天津医科大学基础医学院,天津市300070

出　　处：《中国肿瘤临床》2013年第5期297-300,共4页Chinese Journal of Clinical Oncology

基　　金：天津市应用基础及前沿技术研究项目(编号:10JCYBJC12900)资助~~

摘　　要：Th17细胞在炎症、自身免疫、过敏和肿瘤等多种疾病中发挥着重要作用,但在肿瘤免疫中的作用却知之甚少。本文主要对Th17细胞在肿瘤微环境中分化相关的细胞因子,细胞内的信号传导通路和Th17细胞的迁移活动等内容进行回顾,并进一步阐述其在肿瘤形成过程中所发挥的双向作用,为寻求治疗肿瘤的靶点提供依据。Thl7 cells have important functions in several diseases, including autoimmunity, inflammations, allergies, and tumors. However, the function of these cells in most tumor immunity cases remains unknown. The current study reviewed the current under- standing of molecular interactions, signal pathways, and cell migration that contribute to cell differentiation and functions of Th 17 cells in a tumor microenvironment. This paper also summarized the conclusions regarding the functions of these cells in tumorigenesis to pro- vide basic guidelines for Th 17-targeted therapy of tumors.

关 键 词：TH17细胞 肿瘤微环境 IL-17 

分 类 号：R730.2[医药卫生—肿瘤]