子宫肌瘤危险因素的流行病学调查研究  

The Epidemiological Survey on the Susceptibility to Uterine Leiomyoma

作　　者：沈杨[1] 许茜[2] 徐洁[1] 任慕兰[1] 蔡云朗[1] 

机构地区：[1]东南大学附属中大医院,江苏南京210009 [2]东南大学公共卫生学院,江苏南京210009

出　　处：《实用妇产科杂志》2013年第3期189-193,共5页Journal of Practical Obstetrics and Gynecology

基　　金：南京科技计划项目(项目编号:201201054);东南大学国家自然基金科研项目(项目编号:KJ2010493);东南大学重大科研引导基金项目(项目编号:3290001102);东南大学SRTP项目(项目编号:T11431001)

摘　　要：目的:通过流行病学调查对子宫肌瘤有关的因素进行分析,以期探讨子宫肌瘤患病的危险因素。方法:采用病例对照研究对南京地区、汉族、30～50岁、未绝经女性进行问卷调查,其中300例为2011年2月至2012年3月在东南大学附属中大医院确诊的子宫肌瘤患者(病例组),300例为同期在中大医院就诊的非子宫肌瘤患者或体检健康人群(对照组)。将问卷结果录入数据库,采用单因素及多因素Logistic分析。结果:病例组高中以上学历、平时精神状况一般、经常接触化妆品、经常食用豆浆、经常接触食品添加剂、经常接触塑料制品、偶尔食用蜂蜜的人群所占比例较对照组高(53.0%、64.3%、12.7%、33.3%、15.3%、11.0%、68.0%vs42.0%、56.0%、8.0%、10.0%、2.0%、4.0%、59.3%),差异均有统计学意义(P<0.05)。多因素Logistic回归分析,年龄、文化程度、接触化妆品和塑料制品及食品添加剂、食用豆浆和蜂蜜是子宫肌瘤患病的危险因素(P<0.05)。结论:年龄大、高中以上学历及环境暴露中接触塑料制品、化妆品、食品添加剂,食用含植物雌激素较高的食物,如豆浆、蜂蜜的人群更易患子宫肌瘤,可能是子宫肌瘤的危险因素。Objective：To explore the prevalence of risk factors for uterine leiomyoma by analysis of the epidemiological investigation of the relevant factors of uterine leiomyoma. Methods：We conducted a ques- tionnaire survey on Hart premenopausal women aged from 30 to 50 years in Nanjing using case control stud- y. 300 cases were patients with uterine leiomyoma confirmed in Affiliated Zhongda Hospital of Southeast Uni- versity between February 2011 and March 2012,while 300 cases were patients without uterine leiomyoma or healthy volunteers during the same period. Then we entered the results into database followed by exploring the relationship between risk factors and exposure of uterine leiomyoma with univariate or multivariate uncon- ditional logistic regression analysis. Results：The results of epidemiologic survey showed that the patients a- bove high school, presenting moderate mental state ,occasional and regular exposure to cosmetics and other chemicals, regular consumption of the soybean milk, occasional and regular intake of food additives, exposure to plastic products, or occational consumption of honey, had a higher prevalence of uterine fibroids （53. 0% 64.3% ,12.7% ~33.3% ,15.3% ,11.0% ,68.0%vs 42.0% ~56. 0% ,8.0% ,10. 0% ,2.0% ,4.0% ,59.3%）. All results above had statistically significant differences（ P 〈 0. 05）. Moreover, multivariate non-conditional lo- gistic regression analysis showed age,education, exposure to cosmetics and other chemicals, intake of food additives,consumption of soybean milk and honey were all the risk factors of uterine leiomyoma（ P 〈0. 05）. Conclusions：The older, higher degree of education, as well as some related environmental exposure to plas- tic products, cosmetics and other chemicals, food additives, and intake of food containing higher phytoestro- gens（ soybeam milk, honey）are closely related to uterine leiomyoma prevalence, and may be risk factors for uterine leiomyoma.

关 键 词：子宫肌瘤 环境暴露 LOGISTIC回归分析 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]