MDM2基因rs2279744多态性与肝细胞癌关联性分析  

Association between MDM2 rs2279744 polymorphism and hepatocellular carcinoma

作　　者：李建芳[1] 徐长风[1] 黄永秩[2] 

机构地区：[1]宁波市第二医院消化三科,浙江宁波315010 [2]右江民族医学院附属医院病理学教研室,广西百色533000

出　　处：《中华肿瘤防治杂志》2013年第6期420-422,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨MDM2基因rs2279744多态性与肝细胞癌(HCC)的发病及预后的关系。方法:采用以医院为基础的病例-对照研究方式通过TaqMan-PCR检测分析192例HCC患者和192名健康志原者的MDM2基因rs2279744的基因型,通过Logistic回归、Kaplan-Meier法和Cox比例风险回归模型等分析该多态性与HCC发病及预后的关系。结果:带有MDM2rs2279744G等位基因的基因型(MDM2-TG和-GG)在HCC组的频率要高于对照组(P=1.77×10-9),与不带有G等位基因者(MDM2-TT)相比,其所致HCC发病风险分别为2.86(1.68～4.85)和4.84(2.90～8.09);该多态性增加肿瘤血道转移风险(OR=1.75);生存分析显示,MDM2-TG和-GG影响HCC术后无病生存及总体生存(P<0.01)。结论:MDM2基因rs2279744多态性影响HCC发病及预后。OBJECTIVE： To explore the association between murine double mimute 2 （MDM2）rs2279744 polymor- phism and hepatocellular carcinoma （HCC） risk and prognosis. METHODS： This study was carried out using the hospi- tal-based case-control method,including 192 cases and 192 controls. Logistic regression model, Kaplan-Meier method, and Cox ratio risk regression model were used to analyze the correlation between the polymorphism of MDM2 rs2279744 and the risk and prognosis of HCC. RESULTS： The frequency of MDM2 genotypes with rs2279744 G alleles （MDM2-TG or MDM2-GG） were higher in cases than in controls （P= 1.77 × 10^-9）. These genotypes, compared to the genotype without rs2279744 G alleles,increased 2.86（1.68-4.85） times or 4.84（2.90-8.09） times risk of HCC,respectively. Further- more,this polymorphism increased hematogenous metastasis risk of HCC （OR= 1. 75）. Additionally, survival analysis showed that MDM2-TG and -GG modified the diseases-free survival and overall survival of HCC after curative treat （P〈0.01）. CONCLUSION： These results suggest that MDM2 rs2279744 may modify the risk and prognosis of HCC.

关 键 词：MDM2 癌 肝细胞 多态性 预后 

分 类 号：R735.7[医药卫生—肿瘤]