胃癌组织AKT-2和PGC表达及其临床意义分析  

Expression and clinical significance analysis of AKT-2 and PGC in gastric carcinoma tissues

作　　者：张丽静[1] 王贵吉[1] 裴迎新[2] 韩丹丹[1] 王珊[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科,河南郑州450052 [2]郑州大学公共卫生学院营养与食品卫生学教研室,河南郑州450001

出　　处：《中华肿瘤防治杂志》2013年第6期448-452,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:研究胃癌组织中丝氨酸/苏氨酸激酶(AKT-2)和胃蛋白酶原C(PGC)的表达及其临床意义分析。方法:应用免疫组化SP检测75例胃癌组织、20例萎缩性胃炎组织和15例正常胃黏膜组织标本中AKT-2蛋白和PGC的表达,采用χ2检验分析临床病理因素与上述指标的相关性。结果:胃癌、萎缩性胃炎和胃正常黏膜组织中AKT-2阳性表达率分别为70.7%(53/75)、38.9%(7/20)和26.7%(4/15),在胃癌组织中的表达明显高于萎缩性胃炎组织和胃正常黏膜组织(P值分别为0.003和0.001),但后两者之间差异无统计学意义(P=0.875),且与胃癌的分化程度、浸润深度、淋巴结转移及临床分期有关,P值分别为0.019,0.017,0.027和0.030;胃癌、萎缩性胃炎和胃正常黏膜组织中PGC阳性表达率分别为9.3%(7/75)、65.0%(13/20)和100.0%(15/15),在胃癌组织中的表达明显高于萎缩性胃炎组织和胃正常黏膜组织(P值分别为0.000和0.000),后两者差异有统计学意义(P=0.033),且与胃癌的分化程度及临床分期有关,P值分别为0.037和0.044;胃癌组织中AKT-2与PGC的表达存在负相关性,r=-0.297,P=0.01。结论:胃癌组织中AKT-2的表达明显高于萎缩性胃炎组织和胃正常黏膜组织,而胃癌组织中PGC的表达明显低于萎缩性胃炎组织和胃正常黏膜组织。因此,AKT-2的过表达及PGC的低表达在胃癌早期诊断中发挥重要作用。OBJECTIVE：To study expression of Serine/Threonine Kinase （AKT-2） and Pepsinogen C（PGC） in gas- tric carcinoma,and analyze its clinical significance. METHODS： Immunohistochemistry was used to examine expression of AKT-2 and PGC in 75 gastric carcinoma,20 atrophic gastritis tissues and 15 para-earcinoma normal mucosa tissues. The correlation between AKT-2,PGC and the clinical pathologic factors was analyzed by chi-square test. RESULTS： The posi- tive rates of AKT-2 in gastric carcinoma, atrophic gastritis tissues and para-carcinoma normal mucosa tissues gradually de- clined,were 70.7%（53/75） to 38.9%（7/20） and 26.7%（4/15）. The expression of AKT-2 in gastric carcinoma tissues was significantly higher than that in atrophic gastritis tissues（P=0. 003） and normal tissue （P=0. 001） ,but there was no significant different between the latter two groups （P= 0. 875）. Expression of AKT-2 was significantly correlated with differentiation status （P = 0.019）, infiltration depth （P = 0.017）, lymph node metastasis （P = 0.027） and clinical stage of the cancer （P=0. 030）. The positive rates of PGC in gastric carcinoma,atrophic gastritis tissues and para-carcinoma nor- mal mucosa tissues were 9.3~ （7/75） ,65.0% （13/20）, 100.0% （15/15）. The expression of PGC in gastric carcinoma tis- sues was significantly higher than that in atrophic gastritis tissues （P=0. 000） and normal tissue （P=0. 000）, and there was significant different between the latter two groups （P=0. 033）. Expression of PGC was significantly correlated with differentiation status （P=0. 037） and clinical stage （P=0. 044） of the cancer （P〈0.05）. There was a negative correla- tion between AKT-2 and PGC （r=- 0. 297, P=0.01）. CONCLUSIONS： The expression of AKT-2 in gastric carcinomatissues is significantly higher than that carcinoma tissues is significantly lower AKT-2 and the lowexpression of PGC in atrophic gastritis tissues and normal tissue, but the expression of PGC in gastr

关 键 词：胃肿瘤 丝氨酸 苏氨酸激酶 胃蛋白酶原C 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]