中风膏对大鼠脑缺血再灌注损伤脑梗死体积及细胞凋亡的影响  

Effect of Zhongfeng Ointment on Infarcting Volume and Apoptosis in Rats with Cerebral Ischemia-reperfusion Injury

作　　者：刘志军[1] 杨瑞龙[1] 杨涛[1] 胡敏棣[1] 窦友义[1] 张谦[1] 赵俊喜[1] 

机构地区：[1]甘肃省中医院

出　　处：《中西医结合心脑血管病杂志》2013年第3期337-339,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：甘肃省卫生厅厅列中医药课题基金(GZK-2008-3)

摘　　要：目的探讨中风膏对大鼠脑缺血再灌注损伤的神经保护作用及机制。方法采用线栓法建立大鼠大脑中动脉栓塞(MCAO)模型。观察中风膏对大鼠脑缺血再灌注后大鼠神经功能缺损评分、脑梗死体积、缺血周边区脑细胞凋亡数的影响。结果中风膏可减少脑缺血再灌注后大鼠神经功能缺损评分、脑梗死体积和凋亡细胞数(P<0.05)。结论中风膏对大鼠脑缺血再灌注损伤有神经保护作用。中风膏通过抑制缺血再灌注大鼠脑缺血区细胞凋亡,起到脑保护作用。Objective To observe the effect of Zhongfeng ointment on infarct volume and apoptosis in rats with cerebral ischemia- reperfusion injury. Methods The middle cerebral artery occlusion （MCAO） was established using Longa suture method. Sprague - Dawley （SD） rats were randomly divided into sham group, model group and Zhongfeng ointment group. The neurological deficit scores,infarct volume and apoptosis were observed. Results The neurological deficit scores,infarct volume and apoptosis were de- creased in Zhongfeng ointment group（P〉0.05）. Conclusion Zhongfeng ointment had neuroprotective effects on rats with cerebral ischemia- reperfusion injury,which contributes to inhibiting apoptosis in cerebral ischemic area.

关 键 词：脑缺血再灌注损伤 中风膏 细胞凋亡 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R285.5[医药卫生—临床医学]