子宫腺肌病中增殖细胞核抗原和Livin蛋白的表达及意义  

Expression of livin and PCNA in adenomyosis

作　　者：魏凌云[1] 王赞宏[1] 曹涛[1] 

机构地区：[1]山西医学科学院山西大医院,030032

出　　处：《山西医药杂志（下半月）》2013年第3期259-260,共2页Shanxi Medical Journal

摘　　要：目的探讨子宫腺肌病在位内膜和异位内膜组织中凋亡抑制基因Livin和增殖细胞核抗原(PC-NA)的表达及意义。方法应用免疫组织化学SP法,检测30例子宫腺肌病患者的在位(腺肌病在位内膜组)和异位内膜(腺肌病异位内膜组)及25例正常子宫内膜组织(对照组)中PCNA和Livin蛋白的表达。结果 PCNA蛋白表达在子宫腺肌病在位内膜组低于异位内膜组,高于对照组,三者间差异有统计学意义(P<0.05);Livin蛋白在对照组和子宫腺肌病在位内膜组中无表达,在子宫腺肌病异位内膜组中表达显著(P<0.05)。结论子宫内膜细胞增殖能力增强,细胞凋亡减弱,与子宫腺肌病的发生、发展有关。Objective To study the expression of livin, an apoptosis inhibitor gene, and expression of PC- NA in adenomyosis. Methods Expression of PCNA protein and livin protein were detected by immunohistochem- istry staining in humans ectopic and eutopic endometrial cells （from 30 women with adenomyosis） and eutopic en- dometrial cells （from 25 women without adenomyosis）. Results PCNA expression in eutopic endometrium of ade- nomyosis was stronger than that in control group, and was lower than that in ectopic endometrium of adenomyosis （ P 〈0.05）. There was no livin expression in eutopic endometrium and control group of adenomyosis, Livin ex- pression in ectopic endometrium of adenomyosis was strong（ P 〈0. 05）. Conclusion The apoptosis is inhibited while proliferation is improved, which is related to adenomyosis.

关 键 词：子宫疾病 细胞凋亡 凋亡蛋白抑制因子 增殖细胞核抗原 

分 类 号：R735.7[医药卫生—肿瘤]