饱和恢复法人体核磁共振自旋—晶格弛豫时间成象方法  

WHOLE BODY NMR SPIN-LATTICE RELAXATION TIME IMAGING USING A SATURATION RECOVERY METHOD

作　　者：冯义濂[1] 刘翔[1] 叶青[1] 

机构地区：[1]北京大学

出　　处：《波谱学杂志》1991年第2期229-236,共8页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金

摘　　要：当前,在医学核磁共振成象领域内,临床上广泛采用的是近似的自旋密度象、T1-和T2-加权密度象。但是,由于人体的正常组织和肿瘤之间的密度差别不大,从质子密度象很难区分人体的正常组织与肿瘤,而肿瘤与人体正常组织之间的在弛豫时间T1、T2的数值上差别较大。另外,自七十年代以来,大量关于离体(in vitro)核磁共振弛豫时间测量的文献表明,肿瘤的核磁共振弛豫时间T1,T2值具有明显的规律性,从而利用核磁共振弛豫时间成象的方法,及人体正常组织、良性及恶性肿瘤的活体(in vivo)T1,T2数值的测量,将有助于实现肿瘤识别的定量方法。Currently, the approximate spin-density, Tl -, T2- weighted density MR Imaging are widely used in Clinical MRI. But unfortunately, because the density deferences between human soft tissues and tumors are not large enough, it's difficult to use these methods to distinguish different kinds of tumors. On the other hand, a large number of publications about ' in vitro' NMR relaxation time measurments since 1970's have shown, that the NMR relaxation time of tumors are obviously different from that of human tissues, and it can be used to distinguish tumors. The saturation recovery multi spin-echo method has been used to carry out the pure Spin-Lattice Relaxation Time Imaging. Using this method, one can also measure the in vivo Tl value point by point and the mean value of a special region, by means of ROI special software. Before doing the imaging experiments, the computer simulation of the physical-mathematical model has been done on VAX-11/785 and Micro VAX- Ⅱ systems.

关 键 词：饱和恢复法 人体 NMR 诊断 肿瘤 

分 类 号：R730.4[医药卫生—肿瘤]