海洛因依赖并发癫痫大发作30例临床分析  

Clinical analysis of 30 cases of heroin dependence complicating grand mal seizures

作　　者：黄海锋 王向林 

机构地区：[1]中山市第三人民医院,广东中山528451

出　　处：《中国民康医学》2013年第4期12-13,45,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨海洛因依赖伴癫痫大发作的特点、原因及临床治疗对策。方法:对海洛因依赖自愿戒毒者中伴癫痫大发作30例资料进行回顾性分析。结果:海洛因依赖伴癫痫大发作30例的滥用时间5年以上23例(76.67%);静脉注射者(86.67%)多于烫吸者(13.33%),(χ2=13.204,P<0.01);伴有多药滥用史27例,以BZD类药为多(90%);有苯丙胺类滥用史13例(43.3%)。对BZD类药物依赖者,给予同类药物替代递减治疗,可减少癫痫大发作的发生(χ2=8.919,P<0.01)。结论:海洛因依赖伴癫痫大发作可能与海洛因、多药滥用、静脉注射方式、滥用时间等因素有关,多药滥用者突然停用BZD类药物、减量过快可能诱发癫痫大发作的发作。Objective ：To explore characteristics, causes and clinical countermeasures of heroin dependence complicating grand mal seizures Methods：30 cases of heroin dependence complicating grand mal seizures were retrospectively analyzed. Results： 23 cases（76.67 % ） of drug abuse more than 5 years ; Intravenous drug users （ 86.67 % ） more than hot smokers （ 13.33 % ） （χ2 = 13. 204, P 〈 0.01 ） ; 27 patients with muhi - drug abuse history, the BZD medicines for more than 90% ; 13 cases of abuse of amphetamine - type history （43.3%）. The BZD class of drug addicts were given diminishing similar drug substitution treatment, can reduce the occurrence of grand mal seizures（ X2 = 8. 919, P 〈 0. 01 ）. Conclusion：Heroin dependence complicating grand mal seizuresmay be related to heroin, multi - drug abuse, Intravenous injection, abuse of timeand other factors, drug abusers abrupt discontinuation of BZD drugs, reducing too quickly may be induced grand mal seizures.

关 键 词：海洛因依赖 癫痫大发作 多药滥用 

分 类 号：R749-69[医药卫生—神经病学与精神病学]