乳腺神经内分泌癌3例临床病理分析及文献复习  

Clinicopathologic analysis of three cases with breast neuroendocrine carcinoma and review of the literature

作　　者：谷勤勤[1,2] 周蕾[1,2] 龚晓萌[1,2] 谢群[1,2] 王萍 

机构地区：[1]蚌埠医学院第一附属医院病理科,安徽蚌埠233030 [2]蚌埠医学院病理学教研室,安徽蚌埠233004 [3]上海市第九人民医院病理科,200011

出　　处：《蚌埠医学院学报》2013年第2期145-148,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨乳腺神经内分泌癌的临床病理特点。方法:对3例乳腺神经内分泌癌进行组织学观察和免疫组织化学染色,并复习相关文献。结果:3例均为女性,发病年龄47～57岁。肿块大小1.5～4.5 cm。组织学形态包括:实体性2例,小细胞/雀麦细胞癌1例。3例突触素表达阳性,而嗜铬颗粒蛋白A、细胞角蛋白、神经细胞黏附分子1各在2例中表达阳性。1例小细胞癌患者死亡,另2例患者均生存。结论:乳腺神经内分泌癌是乳腺癌的一种罕见类型,诊断主要依靠病理组织学检查及免疫组织化学染色。Objective： To investigate the elinicopathologic characteristics of breast neuroendocrine carcinoma. Methods： The breast neuroendocrine carcinoma tissue of 3 cases were examined by histopathology and immunohistochemistry and relevant literatures were reviewed. Results ： Three female cases with 1.5 to 4.5 cm of tumor sizes in diameter were 47 to 57 years old. The morphological types of these tumors included solid carcinoma in 2 cases and small cell carcinoma in 1 case. The synaptophysin expression of tumor cells of all cases were stained positive, but the positive expression of chromogranin, cytokeratin and NCAMI of tumor cells of 2 cases were verified. Two cases were alive except one cases death from small cell carcinoma. Conclusions：The breast neuroendocrine carcinoma is a rare type of the breast carcinoma,whose diagnosis should mainly rely on the pathological and histological examination.

关 键 词：乳腺肿瘤 神经内分泌癌 免疫表型 诊断 鉴别 

分 类 号：R737.9[医药卫生—肿瘤]