疏肝健脾中药对肝硬化患者催乳素水平的影响  

Effect of traditional Chinese medicine Shuganjianpi mixture on prolactin levels in patients with liver cirrhosis

作　　者：毛志方[1] 张晨光[1] 孙学强[1] 刘梦汝[1] 

机构地区：[1]蚌埠医学院第二附属医院感染科,安徽蚌埠233040

出　　处：《蚌埠医学院学报》2013年第2期149-150,153,共3页Journal of Bengbu Medical College

摘　　要：目的:观察疏肝健脾中药对肝硬化患者血清催乳素(prolactin,PRL)水平的影响。方法:将60例中医辨证为肝郁脾虚型乙型肝炎肝硬化患者随机分为对照组和治疗组,各30例。对照组静脉给予复方丹参注射液、甘草酸二胺,每天1次;治疗组在对照组治疗的基础上,再口服疏肝健脾中药,每天2次。2组均治疗30 d。观察2组用药前后患者血清丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、总胆红素(TBI)、PRL等指标。结果:2组治疗后ALT、ALB、TBI、PRL的变化差异均无统计学意义(P>0.05),治疗后对照组的ALT和治疗组的ALT、ALB、TBI、PRL水平均较治疗前有不同变化(P<0.05～P<0.01)。结论:疏肝健脾中药可以降低肝郁脾虚型肝炎后肝硬化患者血清PRL的水平。Objective：To investigate the effects of traditional Chinese medicine Shuganjianpi mixture on patients with liver cirrhosis. Methods ： Sixty liver cirrhosis patients determined by traditional Chinese physicians as the type of stagnation of liver-QI with deficiency of the spleen were randomly divided into treatment group and control group. The patients in the control group were injected with Diammonium glycyrrhizinate and compound danshen injection once a day and the treatment group received oral administration of Shuganjianpi mixture twice a day in addition to the above therapy. The therapy lasted for 30 days in both groups. The ALT, ALB, TBI and serum PRL level in all the patients were determined before and after the treatment. Results：The ALT, ALB,TBI and PRL levels in both groups had no significant difference before treatment（ P 〉 0.05 ） ;after the therapy, the ALT in the control group and the ALT, ALB, TBI and PRL levels in the treatment group changed significantly （ P 〈 0.05 to P 〈 0.01 ）. Conclusions ： The traditional Chinese medicine Shuganjianpi mixture can decrease the serum level of PRL in posthepatitic cirrhosis patients determined as type of stagnation of liver-QI with deficiency of the spleen.

关 键 词：肝硬化 催乳素 疏肝健脾 

分 类 号：R575.2[医药卫生—消化系统]