彩色多普勒超声在诊断三阴性乳腺癌中的应用  

Application of color Doppler ultrasound in triple negative breast cancer

作　　者：王萍[1] 童仙君[1] 程遵华[1] 郑颖[1] 项晓宇[1] 董晓燕[1] 黄菊琴[1] 张晓云[2] 薛晓红[3] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院超声诊断科,上海200437 [2]上海中医药大学附属岳阳中西医结合医院病理科,上海200437 [3]上海中医药大学附属岳阳中西医结合医院乳腺科,上海200437

出　　处：《蚌埠医学院学报》2013年第2期192-195,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨彩色多普勒超声在诊断三阴性乳腺癌(TNBC)中的应用价值。方法:169例经彩色多普勒超声诊断乳腺占位性病变,并经手术和病理检查确诊为乳腺癌的患者,根据免疫组织化学染色检测雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)表达情况,分为TNBC组37例和非TNBC组132例,分析比较2组的超声声像图、病理及临床情况。结果:与非TNBC组比较,TNBC组肿块有较清楚边界的比例高(P<0.05),病灶边缘毛刺状的比例低(P<0.05),病灶内部回声较低且较少钙化(P<0.01),病灶后方声影较少衰减(P<0.05),病灶内无血流或较少血流(P<0.05),血流阻力指数<0.7的比例高(P<0.05)。TNBC组腋窝淋巴结转移高于非TNBC组(P<0.05)。结论:TNBC在超声声像图上的表现更倾向于良性肿块。彩色多普勒超声检查在诊断TNBC方面可起到早期诊断或早期提示作用。Objective：To investigate the value of color Doppler ultrasound in the diagnosis of triple negative breast cancer（TNBC）. Methods：One hundred and sixty-nine cases of breast occupying lesions which were diagnosed by color Doppler ultrasound and confirmed as breast cancer by surgery and pathology were divided into TNBC groups（37 cases） and non-TNBC group（ 132 cases） according to the expression of estrogen receptor （ER）, progesterone receptor （PR） and human epidermal growth factor receptor 2 （HER2） determined by immunohistochemical staining. The ultrasonic image, pathological manifestation and clinical condition of the 2 groups were compared and analyzed. Results：Ultrasonic images showed that the TNBC group had a greater proportion in the masses with clear boundary and a smaller proportion in the masses with short burr on the edge than the non-TNBC group（P 〈 0.05 ） ;the TNBC group had lower echoes and less calcification than the non-TNBC group（P 〈 0.01 ）, and its posterior sound shadow was less attenuated （P 〈 0.05） ; most of the masses in TNBC group showed no blood stream or little blood stream （ P 〈 0.05 ） ; the proportion of flow resistance index 〈 0.7 in TNBC group was greater than that in non-TNBC group （ P 〈 0.05 ）. Pathological examinations showed that axillary lymph node metastases occurred more frequently in the TNBC group （ P 〈 0.05 ）. Conclusions： The above features make the mass more likely to be a benign one. The technique of color Doppler ultrasound is of use in the early diagnosis of TNBC.

关 键 词：乳腺肿瘤 超声检查 雌激素受体 孕激素受体 人表皮生长因子受体2 

分 类 号：R737.9[医药卫生—肿瘤]