起搏方式及瑞舒伐他汀钙对起搏术后心房颤动发生率及CRP水平的影响  

Influence of pacing modes and rosuvastatin calcium on atrial fibrillation incidence and CRP concentration after permant pacemark therapy

作　　者：赵建祥[1] 邓新桃[1] 潘闽[2] 郑金国[1] 石桂良[1] 

机构地区：[1]扬州大学医学院附属兴化市人民医院,江苏兴化225700 [2]南通大学附属医院,江苏南通226001

出　　处：《现代医药卫生》2013年第5期652-653,655,共3页Journal of Modern Medicine & Health

基　　金：泰州市科技局资助项目(2009136)

摘　　要：目的探讨心脏起搏方式及瑞舒伐他汀钙对起搏术后血浆中C-反应蛋白(CRP)水平及心房颤动发生率的影响。方法对植入起搏器资料完整且排除心房颤动等因素的缓慢性心律失常患者,按植入起搏器的类型分为双腔起搏治疗(DDD)组与单腔起搏治疗(VVI)组,各组再按是否加用瑞舒伐他汀钙治疗分为2个亚组:治疗组(在常规治疗中加入瑞舒伐他汀钙)与对照组(常规治疗)。测定术前,术后1、6、12、24个月时血浆中CRP水平,并随访观察24个月,记录心房颤动发生率。结果 DDD组与VVI组术后心房颤动发生率以及术后6、12、24个月的CRP水平比较,差异有统计学意义(P<0.05)。术后24个月DDD治疗组与对照组CRP水平比较,差异有统计学意义(P<0.05),心房颤动发生率比较,差异无统计学意义(P>0.05);VVI组2个亚组术前CRP水平比较,差异无统计学意义(P>0.05),术后1、6、12个月的CRP水平及24个月后心房颤动发生率比较,差异有统计学意义(P<0.05)。结论 DDD组起搏方式较VVI组更能降低心房颤动发生率及血浆中CRP水平,瑞舒伐他汀钙能降低起搏术后CRP水平及起搏术后心房颤动发生率。Objective To investigate the influence of pacing modes and rosuvastatin calcium on atrial fibrillation inci- dence and C reactive protein （CRP） concentration after permant pacemark therapy. Methods The patients with implanted pace- maker, excluding slow arrhythmia, were divided into the DDD group and the VVI group according to the types of pacemaker im- plantation. Then each group was redivided into the two subgroups according to whether adding rosuvastatin calcium, the treatment subgroup added with rosuvastatin treatment on the basis of the routine therapy and the control subgToup treated with the routine therapy. The plasma CRP levels were determined before operation, in postoperative 1,6,12,24 months, respectively. And the inci- dence rates of atrial fibrillation were recorded during 24-month follow-up. Results The postoperative incidence rate of atrial fib- rillation and the CRP levels in postoperative 6,12,24 months had statistical differences between the DDD group and VVI group （P〈0.05）. The CRP level in postoperative 24 months showed statistical difference between the DDD group and the control group, but the incidence rate of atrial fibrillation had no statistical difference （P〉0.05）. The preoperative CRP level had no statistical dif- ference between the two subgroups of the VV! group （P〉0.05）, but the CRP levels in postoperative 1,6,12 months and the incidence rate of atrial fibrillation in postoperative 24 months had statistical difference （P〈0.05）. ConclUsion The pacing mode in the DDD group could reduce the incidence of atrial fibrillation and blood CRP level even more than that in the VVI group. Rosuvastatin calcium may be able to reduce the CRP levels and the incidence rate of atrial fibrillation after pacemaker implantation operation.

关 键 词：心脏起搏器 人工 心房颤动 C反应蛋白质 瑞舒伐他汀钙 

分 类 号：R914.5[医药卫生—药物化学]