血液系肿瘤化疗性呕吐治疗的临床研究  

The Study on the Treatment for Chemotherapeutic Vomiting

作　　者：陆益龙[1] 黄非[1] 朱彦[1] 杨苏南 金蓉珍[1] 

机构地区：[1]镇江医学院附属医院血液科,江苏镇江212001

出　　处：《镇江医学院学报》2000年第3期457-459,共3页Journal of Zhenjiang Medical College

摘　　要：目的 :观察血液系统肿瘤化疗性呕吐的发生状况并分析其规律 ,并对其行针对性治疗的研究对探讨化疗性呕吐的防治方法。方法 :统计连续化疗一年以上的 5 4例血液系统肿瘤病例化疗性呕吐的发生状况并行统计学分析。对早期化疗病例于化疗同时分别随机使用胃复安 (2 0mg d)、枢复宁 (8mg d)或不使用止吐药。对已接受 8次以上化疗的病例化疗时分别随机使用胃复安、枢复宁或镇静剂并合用心理暗示治疗三种止吐方法。分别观察其呕吐发生情况及止吐有效率并进行组间比较。结果 :早期化疗病例其第 4次、第 8次及第 9次化疗时化疗性呕吐的发生率明显高于前次 (P <0 .0 1～ 0 .0 5 ) ,枢复宁的止吐效果明显优于胃复安 (P <0 .0 0 5～ 0 .0 5 )。后期化疗的病例镇静剂并心理治疗的止吐效果优于枢复宁、胃复安 (P <0 .0 0 5～ 0 .0 2 5 )。结论 :长期接受强烈化疗的血液系肿瘤患者可会对化疗形成化疗 呕吐的条件反射。Objective:To observe the rule of vomiting during the chemotherapeutic treatment for the hemopatic carcinomatosis patients and study the anti vomiting treatment for them. Methods: We observed the condition of vomiting during chemotherapy in the 54 hemopatic carcinomatosis patients and compared the results of three different anti vomiting treatments(metoclopromide 20mg/d、ondansetron 8mg/d and calmative and psychotherapy)for the vomiting by chemotherapy. Results:The rate of vomiting by 5th、8th、9th chemotherapy was higher than it was in their praevia chemotherapy(P<0.01～0.05). In the three anti vomiting treatments,ondansetron was better than metoclopromide (P<0.01～0.05).The calmative and psychotherapy was the best one for the patients which had been treated by chemotherapy over 8 times(P<0.025～0.005).Conclusion:The patients with hemopatic carcinomatosis after chemotherapy over 8 times must have formed the conditioned reflex between chemotherapy and vomiting and the calmative and psychotherapy combined with ondansetron may be the best anti vomiting treatment.

关 键 词：血液病 肿瘤 化疗 呕吐 治疗 

分 类 号：R733.05[医药卫生—肿瘤]