食管鳞癌组织中CD44v6与E-钙黏蛋白表达及其临床意义  

The expression and clinical significance of CD44v6 and E-cadherin in the esophageal squamous cell carcinoma

作　　者：何赢[1] 张军[1] 王书奎[1] 黄文斌[1] 陈兴国[1] 何帮顺[1] 赵有财[1] 王劲松[1] 

机构地区：[1]南京医科大学附属南京医院南京市第一医院消化病科,江苏省210006

出　　处：《江苏医药》2013年第5期511-513,F0002,共4页Jiangsu Medical Journal

基　　金：南京市医学科技发展基金资助项目(YKK08095)

摘　　要：目的探讨食管鳞癌组织CD44v6与E-钙黏蛋白(E-cad)表达与其临床病理特征的关系。方法采用免疫组化法检测48例食管鳞癌(A组)、23例糜烂性食管炎(B组)和24例正常食管黏膜组织(C组)CD44v6和E-cad的表达,分析其表达与食管鳞癌临床病理特征的关系。结果 A组CD44v6表达明显高于B、C组,而E-cad表达明显低于B、C组(P<0.05)。CD44v6和E-cad的表达与食管鳞癌浸润深度和淋巴结转移密切相关(P<0.05)。食管鳞癌组织中CD44v6和E-cad表达水平呈负相关(r=-0.580,P<0.05)。结论联合检测病变组织中CD44v6与E-cad的表达有望成为食管鳞癌筛查及预后判断的辅助指标。Objective To investigate the expression and clinical significance of CD44v6 and E-cadherin in the esophageal squamous cell carcinoma. Methods With immunohistochemistry, the expressions of CD44v6 and E-cadherin were detected in 48 esophageal squamous carcinoma tissues （group A）,23 erosive esophagitis tissues（group B） and 24 normal esophagus tissues（group C）. The relationship of the expressions of CD44v6 and E-cadherin and clinieopathological characteristics of esophageal squamous cell carcinoma were analyzed. Results Compared to groups of B and C, the expression of CD44v6 was higher, but that of E-cadherin was lower, in group A （P〈0. 05）. The expressions of CD44v6 and E-cadherin were closely related to the depth of invasion and the status of lymph node metastasis of esophageal squamous cell carcinoma （P〈0. 05）. The expression level of CD44v6 was negatively correlated with that of E-cadherin in group A （r=-0. 580, P〈0. 05）. Conclusion Combined detection of CD44v6 and E-cadherin in diseased tissues is hopeful as the adjutant indicators in screening and predicting the prognosis of esophageal squamous cell carcinoma.

关 键 词：食管鳞癌 CD44V6 E-钙黏蛋白 

分 类 号：R735[医药卫生—肿瘤]