幽门螺杆菌、血清胃蛋白酶原与慢性胃病及胃癌的关系  

Association of Helicobacter pylori infection and serum pepsinogen with chronic gastric diseases and gastric cancer

作　　者：黄语嫣[1] 叶建新[1] 高楠[1] 叶妮[1] 钱夷婷[1] 陈卫昌[1] 

机构地区：[1]苏州大学附属第一医院消化病科,江苏省215006

出　　处：《江苏医药》2013年第5期528-530,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(81272737);江苏省医学重点实验室课题(XK201135)

摘　　要：目的探讨幽门螺杆菌(Hp)感染和血清胃蛋白酶原(PG)与慢性胃病、胃癌之间的关系。方法 240例受检者分为浅表性胃炎(A组,40例)、胃溃疡(B组,41例)、慢性萎缩性胃炎(C组,46例)、胃癌(D组,55例)和正常对照(E组,58例)五组。ELISA方法检测患者血清PGⅠ和PGⅡ值;胶体金法检测血清中Hp-IgG抗体。结果与E组比较,B组血清PGⅠ、PGⅡ明显升高(P<0.01),PGⅠ/PGⅡ比值(PGR)显著降低(P<0.01);C组和D组血清PGⅠ水平和PGR均显著降低(P<0.01),而PGⅡ水平明显增高(P<0.05或P<0.01)。E组、A组、B组、C组和D组Hp感染的阳性率分别为56.9%、65.0%、78.0%、69.6%和76.4%,组间差异无统计学意义(P>0.05)。同一组患者血清PGⅠ、PGⅡ及PGR在Hp-IgG抗体阳性组和Hp-IgG抗体阴性组间无统计学差异(P>0.05)。结论异常血清PG可作为癌前病变及胃癌早期的筛查指标。Hp感染对慢性胃病及胃癌患者血清PG水平影响不大。Objective To investigate the relationship of Helicobacter pylori（Hp） infection and serum pepsinogen（PG） with chronic gastric diseases and gastric cancer. Methods Serum levels of PG Ⅰ ,PG Ⅱ and Hp-IgG antibodies were detected by ELISA and colloidal gold method in 240 patients,who were divided into 5 groups of A（40 cases with superficial gastritis）, B（41 cases with gastric ulcer）,C（46 cases with atrophic gastritis）,D（55 cases with gastric cancer） and E（58 cases as normal controls）. Results Compared with group E, serum levels of PG Ⅰ , PG Ⅱ were higher, but the ratio of PG Ⅰ to PG Ⅱ （PGR） was lower,in group B（P〈0. 01）. Serum PG Ⅰ and PGR were lower, but PG Ⅱ was higher, in groups of C and D than those in group E（P〈0. 01 or P〈0. 05）. The positive rates of Hp infection in groups of E,A,B,C and D were 56. 9%,65.0%,78.0%,69. 60% and 76. 4%,respectively（P〉0. 05）. There were no obvious differences in serum PG Ⅰ ,PG Ⅱ and PGR between the cases with anti-Hp IgG positive and those with anti-Hp IgG negative in the same group （P〉0. 05）. Conclusion The changes of serum PG Ⅰ and PG Ⅱ levels may be taken as the indicators for screening gastric cancer and precarcinoma lesions. Hp infection has little effect on serum pepsinogen level in the patients with chronic gastric diseases and gastric cancer.

关 键 词：幽门螺杆菌 胃蛋白酶原 胃癌 

分 类 号：R573[医药卫生—消化系统]