2002—2011年上海市浦东新区居民原发性肾细胞癌的发病与生存情况  

Incidence and survival rates of primary renal cell carcinoma in residents in Pudong New Area in Shanghai, 2002-2011

作　　者：李小攀[1] 孙乔[1] 杨黎明[1] 杨琛[1] 闫蓓[1] 张美玉[1] 李晓莉[1] 吴铮[1] 傅益飞 曹广文[2] 

机构地区：[1]上海市浦东新区疾病预防控制中心肿瘤防治科,上海200136 [2]第二军医大学基础部流行病学教研室,上海200433

出　　处：《肿瘤》2013年第3期245-250,共6页Tumor

基　　金：浦东新区卫生系统重点学科建设项目(编号:PWZxk2010-09)

摘　　要：目的:分析上海市浦东新区原发性肾细胞癌患者的发病和生存情况。方法:以2002—2011年上海市浦东新区常住户籍居民为研究对象,按世界标准人口计算原发性肾细胞癌标化发病率及死亡率,应用Kaplan-Meier法和COX多元回归模型分析不同性别、不同地区、不同TNM分期和是否手术的原发性肾细胞癌患者的生存情况。结果:2002—2011年原发性肾细胞癌新发1905例,男性1234例、女性671例;男性标化发病率(5.71/10万人年)高于女性(3.07/10万人年)。原发性肾细胞癌相关死亡697例,男性453例、女性244例;男性标化死亡率(1.88/10万人年)高于女性(0.92/10万人年)。原发性肾细胞癌患者1～5年生存率分别为74.75%、69.84%、66.38%、63.40%和61.44%。中心城区与其他地区、TNM高分期组与低分期组、手术切除组与非手术组患者的总体生存率之间差异有统计学意义(P=0.040,P<0.001,P<0.001)。不选择手术治疗和TNM高分期是原发性肾细胞癌患者生存率降低的独立危险因素(P<0.001)。结论:浦东新区原发性肾细胞癌的男性发病率和死亡率高于女性,中心城区居民高于区域内其他地区。手术治疗和肿瘤早发现可明显改善原发性肾细胞癌患者的预后。Objective： To investigate the incidence and survival rates of primary RCC （renal cell carcinoma） in residents in Pudong New Area in Shanghai. Methods： The residents in Pudong New Area in Shanghai were recruited in this study during the period 2002-2011. The standardized morbidity and mortality of primary RCC were calculated by world standard population. The survival of primary RCC patients according to gender, resident district, TNM staging and surgical operation was analyzed by Kaplan-Meier method and COX regression analysis. Results： Among 1 905 new cases of primary RCC occurring during 2002-2011, 1 234 were males and 671 were females. The age-standardized incidence rate in males （5.1 7/100 000 person-year）was higher than that in females （3.07/100 000 person-year）. In 697 cases of RCC-related death, 453 were males and 244 were females. The age-standardized mortality in males （1.88/100 000 person-year） was higher than that in females （0.92/100 000 person-year）. The one-, two-, three-, four-, and five-year survival rates of patients with primary RCC were 74.75%, 69.84%, 66.38%, 63.40% and 61.44%, respectively. There was a statistically significant difference in overall survival between central city vs other areas （P = 0.040）, early stage vs advanced stage （P 〈 0.001）, and having surgical operation vs not having surgical operation （P 〈 0.001）. Advanced stage and not having surgical operation were independent risk factors in patients with primary RCC （P 〈 0.001）. Conclusion： The incidence and mortality rates of primary RCC in males and in central city were significantly higher than those in females and in other areas in residents in Pudong New Area in Shanghai, 2002-2011, respectively. Early diagnosis of primary RCC and performance of surgery can significantly improve the prognosis of patients.

关 键 词：肾肿瘤 流行病学 发病率 死亡率 

分 类 号：R737.11[医药卫生—肿瘤]