微小RNA与肿瘤研究进展  

The Research Progress of MicroRNA and Cancer

作　　者：黄鹏 王春友[2] 

机构地区：[1]广东省潮州市潮州医院普外科,广东潮州521000 [2]华中科技大学同济医学院附属协和医院胰腺外科,武汉430022

出　　处：《医学综述》2013年第5期848-850,共3页Medical Recapitulate

摘　　要：微小核糖核酸(miRNA)是一类在生物体中广泛表达的、非编码调节性小分子RNA。成熟的miRNA与RNA诱导沉默复合体结合后,通过与靶mRNA的特定序列互补或不完全互补结合,进而发挥阻遏翻译或引导酶切的功能。miRNA具有多种生物学功能,如调节细胞发育、分化、增殖、凋亡、免疫与应激反应等,并且具有肿瘤抑制因子及癌基因的作用,可能是诊断、治疗肿瘤的一种潜在手段。MicroRNAs（miRNAs） are a class of short regulatory non-coding RNAs widely expressed in living organisms.Mature miRNAs combine with RNA-induced silencing complex and then complementarily or not completely complementarily bind with targeted mRNA to prevent translation or guide digestion of enzyme.MicroRNAs have many biological functions such as regulation of cell growth,differentiation,proliferation and apoptosis,and immune and stress response,as well as tumor suppressor genes and tumor genes,which may be a potential treatment and diagnosis of cancers.

关 键 词：微小核糖核酸 肿瘤 癌基因 抑癌基因 

分 类 号：R730[医药卫生—肿瘤]