光机能化种植体对2型糖尿病大鼠种植体骨结合的影响  

The effect of ultraviolet-photofunctionalization on the integration of titanium implant with bone in type 2 diabetic rats

作　　者：焦铁军[1] 焦晓丽[2] 刘乃彬[1] 王洪亮[1] 谭乃文[1] 石磊[1] 李德华[1] 宋应亮[1] 

机构地区：[1]第四军医大学口腔医学院种植科,西安710032 [2]河北医科大学第二附属医院口腔正畸科

出　　处：《实用口腔医学杂志》2013年第2期156-160,共5页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:81170984)

摘　　要：目的:评价紫外光机能化种植体表面对2型糖尿病大鼠种植体骨结合的影响。方法:将紫外光未处理和紫外光处理种植体植入2型糖尿病大鼠胫骨近骺端,每组16只大鼠32枚种植体。术后4、8周处死取材,通过生物力学测试和硬组织切片分析2组大鼠种植体骨结合的差异。结果:术后4周时生物力学最大拔出力(N),对照组(88.1±13.3),实验组(171.6±24.4)(P<0.05);8周时对照组(107.2±15.0),实验组(221.7±14.6)(P<0.05)。组织学分析显示,4周时对照组骨-种植体接触率(%)(41.7±2.4),实验组(61.1±2.5)(P<0.05);8周时对照组骨-种植体接触率(%)(48.8±2.5),实验组(71.7±4.2)(P<0.05)。结论:光机能化种植体表面可提高2型糖尿病大鼠种植体骨结合。Objective： To study the effects of ultraviolet-treatment of titanium implant on the integration of implant with bone in type 2 diabetic rats. Methods： Ultraviolet- treated titanium implants （ experimental group, n = 32） and un- treated titanium implants （ control group, n -= 32） were inserted into the distal tibia of type 2 diabetic rats respectively. 4 and 8 weeks after implantation, the rats were sac- rificed for histomorphometry analysis and biomechanical test for the evaluation of bone- implant osseointegration. Results： The max bio- mechanical pull-out force（N） was （88.1 ± 13.3） in control group and （ 171.6 ±24.4） in test group（P 〈0.05） 4 weeks after implan- tation, （ 107.2 ± 15.0） and （221.7 ±14.6） （P 〈 0.05 ） 8 weeks after implantation, respectively. Ponceau staining showed that the bone-implant-contact（ % ） was （41.7 ＋ 2.4） in control group and （61.1 ± 2.5） in test group（P 〈 0.05 ） 4 weeks after implantation, （48.8 ± 2.5 ） and （71.7 ± 4.2） （P 〈 0.05 ） 8 weeks after implantation, respectively. Conclusion： Ultraviolet- photofunctionalization may improve bone-implant osseointegration in type 2 diabetic rats.

关 键 词：种植 紫外光 2型糖尿病 种植体-骨结合 

分 类 号：R783.6[医药卫生—口腔医学]