牙釉质表面原位再生釉质六棱柱样含氟磷灰石显微结构  

Microstructure of tooth enamel prism-like fluoridated hydroxyapatite regenerated on enamel surface

作　　者：邢琳[1] 张恺[2] 孙宏晨[1] 张倩[2] 黄洋[1] 董志恒[1] 杨柏[2] 

机构地区：[1]吉林大学口腔医院,长春130021 [2]吉林大学超分子和材料国家重点实验室

出　　处：《实用口腔医学杂志》2013年第2期185-189,共5页Journal of Practical Stomatology

基　　金：吉林省自然科学基金项目(编号:201215050)

摘　　要：目的:用简单化学方法在牙釉质表面原位合成形态可控的类釉质样氟磷灰石结构,模拟牙齿的自然组成及形貌。方法:以常见的化学原料乙二胺四乙酸二钠钙(EDTA-Ca-Na2)、磷酸二氢钠单水化合物(NaH2PO4.H2O)以及氟化钠作为原料,形成前躯体后与基板同时在温和水热条件中相互作用一段时间获得材料。用X射线衍射、红外光谱、扫描电镜、X线电子能谱、MTT实验、抑菌环实验等评价新材料的理化及生物学性能,对变形链球菌有抑制作用。结果:形成的物质主要成分是氟磷灰石,呈典型的六棱柱结构,横截面直径为300 nm、长约6μm,大小均匀,并且呈现一定的长轴取向性。结论:新型材料能够初步模拟牙釉质的形貌、组成,并有一定抑菌功物。Objective： To construct fluoridated hydroxyapatite （FA） enamel prism-like structure on the natural enamel surface of human teeth by a simple chemical approach. Methods： FA enamel prism-like structure with different sizes and shapes were pro- duced on the enamel surface of human teeth by a chemical approach using EDTA-Ca-N%, NaH2P4· H20 and NaF as the react- ants. The physicochemical and biological properties of the enamel-like material were studied by SEM, XRD, FTIR, XPS, MTY as- say and bacterial inhibition ring test. Results： The compacted well-aligned FA crystals were produced, which could grow directly on the enamel surface. The nanorods of the crystal were approximately 6 μm in length and 300 nm in diameter whose physicochemi- cal property and biological performance were similar to those of natural enamel. The enamel-like material showed biocompatibility and certain bacteriostasis. Conclusion： The FA product may simulate the structure, component and decay resistance of human tooth enamel.

关 键 词：釉质龋 氟磷灰石 仿生材料 形态可控合成 

分 类 号：R78[医药卫生—口腔医学]