异种脱细胞真皮基质整复硬腭部腭瘘的临床研究  

Clinical Study of Heterogeneous Acellular Dermal Matrix for Repairing Hard Palatal Fistula

作　　者：张波[1] 李健[1] 

机构地区：[1]湖南省人民医院口腔颌面外科,湖南长沙410005

出　　处：《医学临床研究》2013年第2期246-249,共4页Journal of Clinical Research

摘　　要：【目的】探讨异种脱细胞真皮基质（下称口腔修复膜）修补硬腭部腭瘘的临床疗效。【方法】38例硬腭部腭瘘的患者随机分为治疗组和对照组，治疗组18例患者采用口腔修复膜修补硬腭部腭瘘，对照组20例患者采用传统方法修复硬腭部腭瘘，观察两组患者术后1～3个月手术部位是否再次穿孔及龈颊沟是否变浅。【结果】治疗组在术后1～3个月再次穿孔的发生率为11．1％（2／18）显著低于对照组25．0％（5／20），其差异有统计学意义（P〈0．05）；治疗组龈颊沟变浅发生率为5．5％（1／18）显著低于对照组发生率为90％（18／20），其差异有统计学意义（P〈O．01）。【结论】采用异种脱细胞真皮基质修补硬腭部腭瘘疗效满意，且手术操作简单，对周围组织损伤小，术后龈颊沟变浅的发生率显著降低。[Objective] To explore the clinical efficacy of heterogeneous acellular dermal matrix（Heal-All Oral Biofilm） for repairing hard palatal fistula. [Methods] Thirty-eight patients with hard palate fistula were randomly divided into treatment group and control group. Palatal fistulas of patients in treatment group（ n= 18） was repaired with heterogeneous aeellular dermal matrix. Palatal fistulas of patients in control group（ n = 20） was repaired with traditional method. The recurrence in the closed fistula and the incidence of buccal gingi- val suleus becoming shallow in patients of two groups were observed 1 - 3 months after the operation. [Re- sults] The recurrence rate of closed fistula in treatment group was 11.1 % （2/18） 1-3 months after the opera- tion, which was markedly lower than that in control group（25.0 %, 5/20）, and there was significant differ- ence（ P d0.05）. The incidence of buccal gingival sulcus becoming shallow in treatment group was 5.5 % （1/ 18）, which was markedly higher than that in control group（90%, 18/20）, and there was significant difference （ P d0.01）. [Conclusion] The efficacy of heterogeneous acellular dermal matrix（Oral Biofilm） for repairing hard palatal fistula is satisfactory, and has simple operation, little damage of surrounding tissue and no inci- dence of buccal gingival sulcus becoming shallow after the operation.

关 键 词：瘘 腭 硬 真皮 

分 类 号：R78[医药卫生—口腔医学]