血浆同型半胱氨酸水平与血管性痴呆的相关性研究  

Study on correlation between plasma level of homocysteine and vascular dementia

作　　者：刘玲[1] 刘琦[2] 杨志勇[2] 

机构地区：[1]中国人民解放军驻香港部队医院综合科,香港999077 [2]东莞市太平人民医院神经内科,广东东莞523900

出　　处：《临床和实验医学杂志》2013年第5期352-353,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血浆同型半胱氨酸(Hcy)水平与血管性痴呆的相关性。方法将患者分为观察组(42例)与对照组(50例),分别为血管性痴呆患者和脑梗死非痴呆性患者,对两组患者的Hcy水平进行比较,并对不同病情程度血管性痴呆患者的Hcy水平予以比较。结果观察组患者的Hcy浓度较之对照组相对更高;另外,重度血管性痴呆患者的的Hcy浓度较之中度和轻度血管性痴呆患者明显更高;中度血管性痴呆患者的Hcy浓度较之轻度血管性痴呆患者明显要高,差异均有显著性(P<0.05)。结论血浆Hcy水平与血管性痴呆的发生有着密切关系,临床可通过消除诱发血浆Hcy水平升高的因素治疗血管性痴呆。Objective To analyze and explore the correlation between plasma level of homocysteine and vascular dementia. Methods A total of 92 patients were divided into observation group and control group, 42 of them were suffered from vascular dementia and 50 patients with cerebral infarction without dementia. The plasma levels of homocysteine were compared between these two groups, and the relationship between plasma level of homocysteine and severity of vascular dementia had been studied. Results The plasma level of homocysteine in patients with vas- cular dementia was higher than that of patients with dementia. The plasma level of homocysteine in patients with severe vascular dementia was high- er than that of patients with moderate vascular dementia, and plasma level of homocysteine in patients with moderate vascular dementia was higher than that of patients with mild vascular dementia. Conclusion The relationship between plasma level of homocysteine and the occurrence of vas- cular dementia is very close, and physicians can treat patients with vascular dementia by elimination of factors causing the elevation of plasma level of homocysteine.

关 键 词：血管性痴呆 同型半胱氨酸 相关性 

分 类 号：R749.13[医药卫生—神经病学与精神病学]