非霍奇金淋巴瘤核仁组成区检测的临床意义  

The clinical significance of nucleolar organizer region in non Hodgkin lymphomas

作　　者：勇威本[1] 孟松娘[1] 张运涛[1] 郑文[1] 卫燕[1] 朱军[1] 

机构地区：[1]北京医科大学临床肿瘤学院北京肿瘤医院,邮政编码100036

出　　处：《北京医学》2000年第5期274-276,共3页Beijing Medical Journal

摘　　要：目的　探讨应用核仁组成区嗜银蛋白 ( Ag NOR)染色对非霍奇金淋巴瘤恶性度的分级及与良性淋巴结病变鉴别的意义。方法　应用 Ag NOR染色技术检测良性淋巴结病 15例 ,非霍奇金淋巴瘤 ( NHL) 66例。结果　Ag NOR计数均值 ( x)和标准差 ( s)分别为 :良性淋巴结病 1.85±0 .50 ,低度恶性 NHL 2 .50± 0 .78,中度 NHL 3.95± 2 .0 7,高度 NHL 5.4 7± 2 .4 2 ,T细胞 NHL4 .2 7± 2 .62 ,B细胞 NHL 4 .4 0± 2 .4 2。 Ag NOR均数良性淋巴结病与低度 NHL间无显著性差异( P>0 .0 5) ,但与中度和高度 NHL间均有非常显著性差异 ( P均 <0 .0 0 1) ;低度 NHL、中度 NHL及高度 NHL相互间均有显著性差异 ( P均 <0 .0 5) ;T细胞 NHL与 B细胞 NHL间无显著性差异( P>0 .0 5)。结论　本研究说明 Ag NOR检测对区分 NHL 恶性度 。Objective To investigate the clinical significance of nucleolar organizer region(NOR) staining in the malignant grades of non Hodgkin lymphomas (NHL) and in differentiating NHL from benign lymphadenopathies.Methods Using a silver staining technique,NOR associated proteins were studied in smear samples of 66 NHL and 15 benign lymphadenopathies.Results The mean numbers and standard deviation of AgNOR counts are as follows:benign lymphadenopathy 1.85±0.50,low grade and high grade NHL ( P <0.05),and also between benign lymphadenopathys and intermediate grade as well as high grade NHL ( P <0.001).Conclusions The results indicate that AgNOR counts may help differentiate the malignant grades of NHL,and fifferenteate intermediate grade,high grade NHL from benign lymphadenopathys.But it can't help differentiate low grade NHL from benign lymphadenopathy ( P >0.05),neither can it differentiate T cell NHL from B cell NHL ( P >0.05).

关 键 词：非霍奇金淋巴瘤 核仁组成区 AGNOR染色 

分 类 号：R733.3[医药卫生—肿瘤]