P16蛋白在非小细胞肺癌中的表达及其临床意义  

The expression of P16 protein in non small cell lung cancer and its clinical significance

作　　者：李小钢[1] 付静 赵克熹 史春祥 

机构地区：[1]北京市海淀医院胸外科,邮政编码100080

出　　处：《北京医学》2000年第5期277-279,共3页Beijing Medical Journal

摘　　要：目的　探讨 P16蛋白在非小细胞肺癌 ( NSCLC)及癌旁组织中的表达及临床意义。方法　采用 SP免疫组化方法测定 P16蛋白在 64例 NSCL C及癌旁 1～ 2 cm组织中的表达。结果　P16蛋白的阳性表达主要位于细胞胞浆 ,部分同时出现于胞核。P16蛋白在 NSCL C中的表达率为4 0 .6% ,在癌旁组织中的表达率为 74 .4 % ,与 NSCL C的分化程度及患者术后生存期有关 ( P<0 .0 5) ,而与组织学类型及有无局部淋巴结转移无明显关系 ( P>0 .0 5)。结论　 P16蛋白表达缺失可作为临床判断 NSCLObjective To elucidate the expression of P16 in non small cell lung cancer (NSCLC) and the tissue adjacent to carcinoma and its clinical significance.Methods Streotavidin perxidase immunohistochemical staining method was used to examine the expression of P16 in 64 NSCLC and the tissue adjacent tocarcinoma.Results The expression of P16 protein was mainly located in cytoplasmin.The positive rate of P16 protein in NSCLC was 40.6%,much lower than 74.4% in the tissue adjacent carcinoma.The positive rate of P16 protein was related to the degree of differentiation and prognosis ( P <0.05),but it not correlate with lymph node metastasis and histologic type ( P >0.05).Conclusions The absence of P16 protein expression may be con sidered as a parameter for judging the degree of differentiation of NSCLC and clinical prognosis.

关 键 词：非小细胞肺癌 P16蛋白 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]