曲唑酮与丙咪嗪治疗抑郁症的比较  

Trazodone vs Imipramine in the treatment of depression

作　　者：曾昭祥[1] 

机构地区：[1]山东省济宁医学院附属第二医院,272151

出　　处：《医药导报》2000年第5期448-449,共2页Herald of Medicine

摘　　要：目的 :比较曲唑酮与丙咪嗪治疗抑郁症的疗效。方法 :将 5 2例患者分为曲唑酮组、丙咪嗪组各 2 6例 ,初始剂量均为 5 0mg d ,10d内加至 15 0～ 3 0 0mg d ,疗程 4周。用HAMD量表评定效果。结果 :两组抗抑郁疗效相仿。HAMD总分及各因子分的减分率两组间比较均差异不显著 ( P >0 .0 5 )。曲唑酮组的主要不良反应为嗜睡 ,丙咪嗪组为口干、便秘、视力模糊等 ,对心脏的影响曲唑酮组明显较丙咪嗪组为轻。结论 :曲唑酮是一种快速、强效、安全的抗抑郁药。Objective:To compare trazodone with imipramine in the treatment of depression. Method:52 patients were radomly divided into 2 groups, 26 paitents (M 15, F 11; age 36.7±12.5 years) were treated with trazodone, 26 patients (M 16, F 10; age 37.4±11.8 years) were treated with imipramine. The initial dose 50 mg/d was gradually increased to 150～300 mg/d within ten days for 4 weeks. The symptoms of all patients were assessed with HAMD before and after treatment. Results:Antidepressive efficacies of two drugs were almost the equivalent. Decrease of total HAMD scores and each factor scores in two groups were not statistically significant (P>0.05). The main adverse reaction of trazodone was calm, that of imipramine was anticholinergic effect (dry mouth, constipation, blurring of vision). Conclusion:Trazodone is a rapid, powerful, and safe drug for treatment of depression.

关 键 词：曲唑酮 丙咪嗪 抑郁症 药物疗法 治疗 

分 类 号：R749.410.5[医药卫生—神经病学与精神病学]